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Determinants of plasma adiponectin levels in obese children

Authors
 Eun-Gyong Yoo  ;  Duk Hee Kim 
Citation
 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol.21(8) : 737-743, 2008 
Journal Title
 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 
ISSN
 0334-018X 
Issue Date
2008
MeSH
Adiponectin/blood ; Blood Pressure/physiology ; Body Mass Index ; Case-Control Studies ; Child ; Female ; Humans ; Insulin Resistance/physiology ; Lipids/blood ; Male ; Obesity/blood* ; Sex Characteristics ; Waist-Hip Ratio
Keywords
Adiponectin/blood ; Blood Pressure/physiology ; Body Mass Index ; Case-Control Studies ; Child ; Female ; Humans ; Insulin Resistance/physiology ; Lipids/blood ; Male ; Obesity/blood* ; Sex Characteristics ; Waist-Hip Ratio
Abstract
Adiponectin is an insulin-sensitizing adipocytokine, and recently it has been suggested as a biomarker of metabolic syndrome. We studied the relationships between adiponectin and parameters of metabolic syndrome in obese children. Fasting plasma adiponectin, insulin, glucose, lipids, and anthropometric parameters were measured in 180 obese children and 125 non-obese controls. Adiponectin was significantly decreased in obese boys and girls compared to non-obese controls. Adiponectin was inversely related to body mass index, waist circumference (WC), insulin, homeostasis model assessment for insulin resistance, and triglycerides, after adjusting for age in both genders. Adiponectin was correlated with high-density lipoprotein cholesterol (HDL-C) after adjusting for age in both genders. In multiple regression analysis, WC was independently related to adiponectin in boys, and WC and HDL-C were independently related to adiponectin in girls. In conclusion, WC, a simple measure of central adiposity, is a determinant of adiponectin in obese children.
Full Text
http://www.degruyter.com/view/j/jpem.2008.21.8/jpem.2008.21.8.737/jpem.2008.21.8.737.xml;jsessionid=81F172DC98DA0AA77DD16082223E416D
DOI
18825873
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107661
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