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Comparison of sirolimus-eluting stent and paclitaxel-eluting stent for long-term cardiac adverse events in diabetic patients: the Korean Multicenter Angioplasty Team (KOMATE) Registry.

Authors
 Jung-Sun Kim  ;  Byoung Ho Lee  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Pil-Ki Min  ;  Young-Won Yoon  ;  Bum Kee Hong  ;  Hyuck Moon Kwon  ;  Min-Soo Ahn  ;  Seung-Hwan Lee  ;  Jung Han Yoon  ;  Byoung Kwon Lee  ;  Byung Ok Kim  ;  Byeong-Kuk Kim  ;  Sung Jin Oh  ;  DongWoon Jeon  ;  Joo Young Yang  ;  Jung Rae Cho  ;  Jae-Hun Jung  ;  Seung-Ki Ryu 
Citation
 Catheterization and Cardiovascular Interventions, Vol.72(5) : 601-607, 2008 
Journal Title
 Catheterization and Cardiovascular Interventions 
ISSN
 1522-1946 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary*/adverse effects ; Angioplasty, Balloon, Coronary*/instrumentation ; Angioplasty, Balloon, Coronary*/mortality ; Cardiovascular Agents/administration & dosage* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control* ; Coronary Angiography ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/mortality ; Coronary Stenosis/therapy* ; Diabetes Complications/diagnostic imaging ; Diabetes Complications/mortality ; Diabetes Complications/therapy* ; Disease-Free Survival ; Drug-Eluting Stents* ; Female ; Humans ; Korea ; Male ; Middle Aged ; Paclitaxel/administration & dosage* ; Registries ; Risk Assessment ; Sirolimus/administration & dosage* ; Time Factors ; Treatment Outcome
Keywords
Adult ; Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary*/adverse effects ; Angioplasty, Balloon, Coronary*/instrumentation ; Angioplasty, Balloon, Coronary*/mortality ; Cardiovascular Agents/administration & dosage* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control* ; Coronary Angiography ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/mortality ; Coronary Stenosis/therapy* ; Diabetes Complications/diagnostic imaging ; Diabetes Complications/mortality ; Diabetes Complications/therapy* ; Disease-Free Survival ; Drug-Eluting Stents* ; Female ; Humans ; Korea ; Male ; Middle Aged ; Paclitaxel/administration & dosage* ; Registries ; Risk Assessment ; Sirolimus/administration & dosage* ; Time Factors ; Treatment Outcome
Abstract
BACKGROUND: There is some controversy on long-term cardiac outcomes between sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in diabetes mellitus (DM). We compared cardiac adverse events after SES and PES implantation in patients with DM over a period of 3 year. METHODS: A total of 634 patients with DM treated with SES (n = 428) or PES (n = 206) were consecutively enrolled in the KOMATE registry from 2003 to 2004. We assessed major adverse cardiac events (MACEs, cardiovascular death, nonfatal myocardial infarction, ischemia driven target vessel revascularization) and stent thrombosis (ST) according to the definitions set by the Academic Research Consortium. RESULTS: Propensity score (PS) analysis was performed to adjust different baseline characteristics. The mean follow-up duration was 38 +/- 8 month (at least 36 month and up to 53 month). The 3-year MACE rate did not show a significant difference between the two groups [52 (12.1%) in SES vs. 29 (14.1%) in PES, P = 0.496]. The definite and probable ST at 3 year were similar in both SES and PES [12 (2.8%) in SES vs. 7 (3.4%) in PES, P = 0.681]. There were no differences in hazard ratio for MACE and ST between two stents [MACE, crude: 0.844 (0.536-1.330) and adjusted for PS: 0.858 (0.530-1.389); ST, crude: 0.820 (0.323-2.083) and adjusted for PS: 0.960 (0.357-2.587)]. CONCLUSIONS: The present study demonstrated that long-tem cardiac outcomes including ST were not significantly different between SES and PES in patients with DM.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ccd.21700/abstract
DOI
10.1002/ccd.21700
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Lee, Byung Ho(이병호)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107658
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