1 494

Cited 73 times in

The effect of cyclic strain on embryonic stem cell-derived cardiomyocytes

DC Field Value Language
dc.contributor.author김일권-
dc.contributor.author유경종-
dc.date.accessioned2015-05-19T17:09:09Z-
dc.date.available2015-05-19T17:09:09Z-
dc.date.issued2008-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107600-
dc.description.abstractCardiomyocytes in the body are subjected to cyclic mechanical strain induced by the rhythmic heart beating. In this study, we tested the hypothesis that cyclic strain promotes cardiomyogenesis of embryonic stem cell-derived cardiomyocytes (ESCs). ESCs cultured on elastic polymer [poly(lactide-co-caprolactone), PLCL] scaffolds subjected to cyclic strain in vitro displayed elevated cardiac gene expression compared to unstrained controls. Six weeks after implantation into infarcted rat myocardium, the elastic cardiac patches (ESC-seeded PLCL scaffolds) showed reduced fibrotic tissue formation, likely due to a combination of lower apoptotic activity, higher vascular endothelial growth factor (VEGF) expression, and more extensive angiogenesis in the strained versus unstrained control [ESC-seeded, non-elastic poly(lactide-co-glycolide) scaffolds] patches. Importantly, cardiac gene expression was upregulated in the elastic patches compared to control, with evidence for cardiomyocyte-specific microstructures including myofibrillar bundles and Z-lines. This study shows that the use of an elastic polymer scaffold designed to permit mechanical strain transduction as a cell transplantation vehicle significantly increases cardiomyogenesis of the implanted ESCs.-
dc.description.statementOfResponsibilityopen-
dc.format.extent844~856-
dc.relation.isPartOfBIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe effect of cyclic strain on embryonic stem cell-derived cardiomyocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorSo-Jung Gwak-
dc.contributor.googleauthorSuk Ho Bhang-
dc.contributor.googleauthorIl-Kwon Kim-
dc.contributor.googleauthorSang-Soo Kim-
dc.contributor.googleauthorSeung-Woo Cho-
dc.contributor.googleauthorOju Jeon-
dc.contributor.googleauthorKyung Jong Yoo-
dc.contributor.googleauthorAndrew J. Putnam-
dc.contributor.googleauthorByung-Soo Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00848-
dc.contributor.localIdA02453-
dc.relation.journalcodeJ00312-
dc.identifier.eissn1878-5905-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0142961207008617-
dc.contributor.alternativeNameKim, Il Kwon-
dc.contributor.alternativeNameYoo, Kyung Jong-
dc.contributor.affiliatedAuthorKim, Il Kwon-
dc.contributor.affiliatedAuthorYoo, Kyung Jong-
dc.rights.accessRightsnot free-
dc.citation.volume29-
dc.citation.number7-
dc.citation.startPage844-
dc.citation.endPage856-
dc.identifier.bibliographicCitationBIOMATERIALS, Vol.29(7) : 844-856, 2008-
dc.identifier.rimsid53331-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.