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Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas

Authors
 Kwi Hye Koh  ;  Hwanseok Rhee  ;  Hyun Ju Kang  ;  Eungi Yang  ;  Kwon Tae You  ;  Hanna Lee  ;  Byung Soh Min  ;  Nam Kyu Kim  ;  Suk Woo Nam  ;  Hoguen Kim 
Citation
 ONCOLOGY, Vol.75(1-2) : 92-101, 2008 
Journal Title
 ONCOLOGY 
ISSN
 0030-2414 
Issue Date
2008
MeSH
Aged ; Colorectal Neoplasms/genetics* ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Female ; Gene Expression Profiling* ; Humans ; Liver Neoplasms/genetics* ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis
Keywords
Colon carcinomas ; Gene expression ; Metastasis ; Microarray
Abstract
BACKGROUND AND METHODS: Despite the overwhelming clinical significance of metastases, the cellular and molecular mechanisms involved are largely unknown. In order to define significant differences between primary colon carcinomas and their metastases, we analyzed gene expression profiles of 12 sets of triple-paired tissues using 19 K human oligonucleotide microarrays. A total of 36 microarray experiments were analyzed by unsupervised two-way hierarchical clustering and multi-dimensional scaling (MDS). RESULTS: Both methods completely distinguished normal mucosa from carcinoma, but failed to demonstrate a complete classification of primary and metastatic carcinomas. We found a separable tendency to be classified into the primary and metastatic colon carcinomas by MDS. In supervised hierarchical clustering, we identified 80 genes that were differentially expressed between paired primary and metastatic colon carcinomas. The 80 identified genes also successfully distinguished three validation sets of primary and lung-metastatic colon carcinomas. A specific set of genes was identified that distinguished the metastasis from the corresponding primary tumor in nearly half of the metastases analyzed. CONCLUSIONS: We suggest that a more accurate model of the metastatic potential is based on a global tumor expression pattern along with the appearance of distinct metastatic variants. This molecular profiling may be useful for the future study of colon cancer metastasis.
Full Text
http://www.karger.com/Article/FullText/155211
DOI
10.1159/000155211
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Clinical Genetics (임상유전학과) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Ju(강현주)
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Hogeun(김호근)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
You, Kwon Tae(유권태)
Lee, Hanna(이한나)
Rhee, Hwan Seok(이환석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107526
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