Cited 17 times in
Tumor necrosis factor-alpha and interleukin-10 in whole blood is associated with disease progression in pulmonary multidrug-resistant tuberculosis patients
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-05-19T17:06:07Z | - |
dc.date.available | 2015-05-19T17:06:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107508 | - |
dc.description.abstract | BACKGROUND: Cytokine production profiles may reflect the clinical pictures of patients with tuberculosis (TB). OBJECTIVE: We examined the relationship between cytokine levels and clinical parameters indicating the state of disease in active pulmonary TB patients. METHODS: We measured interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 levels in whole blood after stimulation with culture filtrate protein of Mycobacterium tuberculosis in 33 multi-drug resistant (MDR)-TB and 51 non-MDR-TB patients. RESULTS: No significant difference was found in IFN-gamma production between non-MDR-TB and MDR-TB patients, but there was a marked reduction in TNF-alpha production in MDR-TB patients accompanied by a moderate increase in IL-10 levels. In contrast, the presence of cavity was associated with a significant increase in IFN-gamma, whereas no difference in TNF-alpha between the cavity and non-cavity group was observed. Those who have TB lesions in the left lung showed lower levels of IFN-gamma and TNF-alpha and higher IL-10 levels than the patients with lesions on the right side. IFN-gamma levels were significantly increased in those with moderate or advanced lesions compared with patients with mild lesions. TNF-alpha and IL-10 levels did not change with disease severity. The number of M. tuberculosis bacilli in sputum was closely associated with TNF-alpha levels. The patient group with high value (+++) of sputum culture acid-fast bacilli produced significantly reduced levels of TNF-alpha compared with medium (++) and low (+) values. CONCLUSION: These findings suggest that IFN-gamma, TNF-alpha or IL-10 production patterns in whole blood are associated with disease progression in active pulmonary TB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 331~337 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Disease Progression* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/blood | - |
dc.subject.MESH | Interleukin-10/blood* | - |
dc.subject.MESH | Lung/diagnostic imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Radiography | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Sputum/microbiology | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/blood* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/diagnostic imaging | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/blood* | - |
dc.title | Tumor necrosis factor-alpha and interleukin-10 in whole blood is associated with disease progression in pulmonary multidrug-resistant tuberculosis patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Seok-Yong Eum | - |
dc.contributor.googleauthor | Bo-Young Jeon | - |
dc.contributor.googleauthor | Jin-Hong Min | - |
dc.contributor.googleauthor | Seung-Cheol Kim | - |
dc.contributor.googleauthor | Sungae Cho | - |
dc.contributor.googleauthor | Seung-Kyu Park | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.identifier.doi | 10.1159/000113932 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02613 | - |
dc.identifier.eissn | 1423-0356 | - |
dc.identifier.pmid | 18212516 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/113932 | - |
dc.subject.keyword | Pulmonary tuberculosis | - |
dc.subject.keyword | Multi-drug resistance | - |
dc.subject.keyword | Cavity | - |
dc.subject.keyword | Acid-fast bacilli | - |
dc.subject.keyword | Cytokines | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 76 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 331 | - |
dc.citation.endPage | 337 | - |
dc.identifier.bibliographicCitation | RESPIRATION, Vol.76(3) : 331-337, 2008 | - |
dc.identifier.rimsid | 56916 | - |
dc.type.rims | ART | - |
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