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소아암 환자의 치료가 갑상선 기능에 미치는 후기 영향

Other Titles
 Late Effect of Pediatric Cancer Therapy on Thyroid Function 
 김효선  ;  한정우  ;  권승연  ;  원성철  ;  유철주 
 Clinical Pediatric Hematology-Oncology, Vol.15(1) : 10-16, 2008 
Journal Title
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양) 
Issue Date
Children ; Cancer ; Long-term survivors ; Thyroid function tests ; Complications
Purpose: According to advances in childhood cancer therapy, survival outcomes are markedly improved during the past few decades. On the other hand, late effects of childhood cancer survivors are nowadays having been issued owing to its importance of early detection and proper management. It is now known from references abroad that thyroid disorders have frequently occurred in long-term survivors since endocrine organs are sensitive to both cytotoxic drugs and radiation. However, research in Korea has not been published yet. The aim of this study was to investigate the late effect of cancer therapy on thyroid disorders in childhood cancer survivors. Methods: Medical records of 129 childhood cancer survivors who visited long term follow up clinic between 2005 and 2008 were retrospectively reviewed. Clinical characteristics including individual cancer therapy were reviewed. We analyzed the relationship between thyroid function status with variable clinical factors and types of cancer therapy. Results: The incidence of thyroid dysfunction was 30.2% (39/129) in long-term survivors with cancer therapy. Thyroid dysfunction were more frequently in patients treated with radiotherapy (P=0.021) and stem cell transplantation (P=0.001). We also found a significant association between underlying disease and thyroid dysfunction (P<0.001). Conclusion: These findings emphasize the need for long-term follow-up of thyroid function in childhood cancer survivors after radiotherapy or/and stem cell transplantation in order to offer proper treatment.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
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