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Is electrical stimulation beneficial for improving the paralytic effect of botulinum toxin type A in children with spastic diplegic cerebral palsy?

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dc.contributor.author나동욱-
dc.contributor.author박은숙-
dc.contributor.author박창일-
dc.date.accessioned2015-05-19T17:00:16Z-
dc.date.available2015-05-19T17:00:16Z-
dc.date.issued2008-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107346-
dc.description.abstractPURPOSE: The purpose of the present study was to investigate whether electrical stimulation (ES) improves the paralytic effect of botulinum toxin type A (BTX-A) and evaluate the differences between low frequency (LF) and high frequency (HF) ES in children with spastic diplegic cerebral palsy (CP). MATERIALS AND METHODS: Twenty-three children with spastic diplegia CP who had BTX-A injections into both gastrocnemius muscles were assessed. Following the toxin injection, electrical stimulation was given to 1 side of the injected muscles and a sham-stimulation to the other side for 30 min a day for 7 consecutive days [HFES (25Hz) to 11 children, LFES (4Hz) to 12 children]. The compound motor action potentials (CMAP) from the gastrocnemius muscle were assessed before injection and at 5 time points (days 3, 7, 14, 21, and 30) after injection. The clinical assessments of spasticity were performed before and 30 days after injection. RESULTS: The CMAP area became significantly lower in both LFES and HFES sides from 3 days after injection compared to baseline values. In other words, the CMAP area of the sham-stimulated side showed a significant decrease at 7 or 14 days after injection. However, there were no significant differences in clinical assessment of spasticity between the stimulated and sham-stimulated sides. CONCLUSION: Short-term ES in both LF and HF to the spastic muscles injected with BTX-A might induce earlier denervating action of BTX-A. However, it does not necessarily lead to clinical and electrophysiological benefits in terms of reduction of spasticity.-
dc.description.statementOfResponsibilityopen-
dc.format.extent545~552-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBotulinum Toxins, Type A/therapeutic use*-
dc.subject.MESHCerebral Palsy/drug therapy*-
dc.subject.MESHCerebral Palsy/physiopathology*-
dc.subject.MESHChild, Preschool-
dc.subject.MESHElectric Stimulation-
dc.subject.MESHElectrophysiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHParalysis/drug therapy*-
dc.subject.MESHParalysis/physiopathology*-
dc.titleIs electrical stimulation beneficial for improving the paralytic effect of botulinum toxin type A in children with spastic diplegic cerebral palsy?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학)-
dc.contributor.googleauthorDong-wook Rha-
dc.contributor.googleauthorEun Joo Yang-
dc.contributor.googleauthorHo Ik Chung-
dc.contributor.googleauthorHyoung Bin Kim-
dc.contributor.googleauthorChang-il Park-
dc.contributor.googleauthorEun Sook Park-
dc.identifier.doi10.3349/ymj.2008.49.4.545-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01230-
dc.contributor.localIdA01611-
dc.contributor.localIdA01717-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid18729296-
dc.subject.keywordBotulinum toxin type A-
dc.subject.keywordelectrical stimulation-
dc.subject.keywordcerebral palsy-
dc.subject.keywordspasticity-
dc.contributor.alternativeNameRha, Dong Wook-
dc.contributor.alternativeNamePark, Eun Sook-
dc.contributor.alternativeNamePark, Chang Il-
dc.contributor.affiliatedAuthorRha, Dong Wook-
dc.contributor.affiliatedAuthorPark, Eun Sook-
dc.contributor.affiliatedAuthorPark, Chang Il-
dc.rights.accessRightsfree-
dc.citation.volume49-
dc.citation.number4-
dc.citation.startPage545-
dc.citation.endPage552-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.49(4) : 545-552, 2008-
dc.identifier.rimsid45054-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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