Cited 17 times in
Is electrical stimulation beneficial for improving the paralytic effect of botulinum toxin type A in children with spastic diplegic cerebral palsy?
DC Field | Value | Language |
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dc.contributor.author | 나동욱 | - |
dc.contributor.author | 박은숙 | - |
dc.contributor.author | 박창일 | - |
dc.date.accessioned | 2015-05-19T17:00:16Z | - |
dc.date.available | 2015-05-19T17:00:16Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107346 | - |
dc.description.abstract | PURPOSE: The purpose of the present study was to investigate whether electrical stimulation (ES) improves the paralytic effect of botulinum toxin type A (BTX-A) and evaluate the differences between low frequency (LF) and high frequency (HF) ES in children with spastic diplegic cerebral palsy (CP). MATERIALS AND METHODS: Twenty-three children with spastic diplegia CP who had BTX-A injections into both gastrocnemius muscles were assessed. Following the toxin injection, electrical stimulation was given to 1 side of the injected muscles and a sham-stimulation to the other side for 30 min a day for 7 consecutive days [HFES (25Hz) to 11 children, LFES (4Hz) to 12 children]. The compound motor action potentials (CMAP) from the gastrocnemius muscle were assessed before injection and at 5 time points (days 3, 7, 14, 21, and 30) after injection. The clinical assessments of spasticity were performed before and 30 days after injection. RESULTS: The CMAP area became significantly lower in both LFES and HFES sides from 3 days after injection compared to baseline values. In other words, the CMAP area of the sham-stimulated side showed a significant decrease at 7 or 14 days after injection. However, there were no significant differences in clinical assessment of spasticity between the stimulated and sham-stimulated sides. CONCLUSION: Short-term ES in both LF and HF to the spastic muscles injected with BTX-A might induce earlier denervating action of BTX-A. However, it does not necessarily lead to clinical and electrophysiological benefits in terms of reduction of spasticity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 545~552 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Botulinum Toxins, Type A/therapeutic use* | - |
dc.subject.MESH | Cerebral Palsy/drug therapy* | - |
dc.subject.MESH | Cerebral Palsy/physiopathology* | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Electric Stimulation | - |
dc.subject.MESH | Electrophysiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Paralysis/drug therapy* | - |
dc.subject.MESH | Paralysis/physiopathology* | - |
dc.title | Is electrical stimulation beneficial for improving the paralytic effect of botulinum toxin type A in children with spastic diplegic cerebral palsy? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | Dong-wook Rha | - |
dc.contributor.googleauthor | Eun Joo Yang | - |
dc.contributor.googleauthor | Ho Ik Chung | - |
dc.contributor.googleauthor | Hyoung Bin Kim | - |
dc.contributor.googleauthor | Chang-il Park | - |
dc.contributor.googleauthor | Eun Sook Park | - |
dc.identifier.doi | 10.3349/ymj.2008.49.4.545 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01230 | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01717 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 18729296 | - |
dc.subject.keyword | Botulinum toxin type A | - |
dc.subject.keyword | electrical stimulation | - |
dc.subject.keyword | cerebral palsy | - |
dc.subject.keyword | spasticity | - |
dc.contributor.alternativeName | Rha, Dong Wook | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Rha, Dong Wook | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 545 | - |
dc.citation.endPage | 552 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.49(4) : 545-552, 2008 | - |
dc.identifier.rimsid | 45054 | - |
dc.type.rims | ART | - |
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