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Clinical manifestations associated with high titer of anti-streptolysin O in Behcet's disease

Authors
 Sang Ho Oh  ;  Kyu-yeop Lee  ;  Ju Hee Lee  ;  Dongsik Bang 
Citation
 CLINICAL RHEUMATOLOGY, Vol.27(8) : 999-1003, 2008 
Journal Title
 CLINICAL RHEUMATOLOGY 
ISSN
 0770-3198 
Issue Date
2008
MeSH
Adult ; Antibodies, Bacterial/analysis* ; Bacterial Proteins/immunology ; Behcet Syndrome/immunology* ; Behcet Syndrome/microbiology ; Cohort Studies ; Female ; Humans ; Male ; Odds Ratio ; Stomatitis, Aphthous/immunology ; Streptococcal Infections/immunology* ; Streptococcus pyogenes/immunology* ; Streptolysins/immunology*
Keywords
Anti-streptolysin O ; Behcet’s disease ; Streptococcus
Abstract
To evaluate the association of chronic infection with clinical features of Behcet's disease (BD), we studied epidemiological and clinical features of 149 patients with only aphthous ulcer and 294 patients with BD. The incidence of chronic infection history was compared between both groups with age- and sex-matching and clinical manifestations of BD associated with high anti-streptolysin O (ASO) titer were investigated. BD patients had more common history of tonsillitis and dental caries than aphthous ulcer patients (P = 0.002 and P = 0.043, respectively). BD patients with persistently high anti-streptolysin O titers had more frequent history of tonsillitis (P = 0.001, odds ratio [OR] = 2.99, 95% confidence interval [CI] 1.53-5.82) and erythema nodosum (EN)-like lesions (P = 0.001, OR = 3.02, 95% CI 1.54-5.93) and fewer history of genital ulcer (P = 0.027, OR = 0.21, 95% CI 0.05-0.84) than BD patients with normal anti-streptolysin O titer. Our results suggest persistently high ASO titers in BD patients could indicate that streptococcal infections such as tonsillitis are related to BD symptoms such as EN-like lesions. In these patients, ASO titer can be used in the evaluation of BD disease activity and antibiotic treatments might be effective to control the symptoms of BD
Full Text
http://link.springer.com/article/10.1007%2Fs10067-008-0844-x
DOI
10.1007/s10067-008-0844-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107317
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