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베체트병에서 MIF 발현에 대한 연구

Other Titles
 Expression of Macrophage Migration Inhibitory Factor in Beh?et's Disease 
Authors
 인성일  ;  백진아  ;  박경숙  ;  방동식  ;  이은소 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.46(5) : 611-618, 2008 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
ISSN
 4944-4739 
Issue Date
2008
Keywords
Behçet’s disease ; Macrophage migration inhibitory factor
Abstract
Background: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-polymorphisms are associated with an increased risk for various inflammatory diseases. Objective: This study was designed to investigate the effect of MIF polymorphisms on Behcet`s disease (BD). Methods: A total of 362 patients with BD and 290 healthy controls were genotyped. We also performed RT-PCR analysis, ELISA, and immunohistochemical stain for MIF. Results: We could not find statistically significant differences in the genotype frequencies of the MIF-794[CATT]5-8 repeat polymorphism or MIF-173 G>C polymorphism between BD patients and controls. Immunohistochemical analysis showed that MIF protein was diffusely distributed throughout epidermis and subcutaneous fat tissue from the skin lesions of patients with BD and erythema nodosum. Conclusion: Contrary to earlier reports, serum MIF levels were decreased in patients with BD, and the prescence of polymorphisms in the MIF promoter region was not associated with disease susceptibility. Nevertheless, MIF may play a role in cutaneous inflammation in BD
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107316
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