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레녹스 가스토 증후군에서 뇌량절제술

Other Titles
 Corpus Callosotomy in Lennox-Gastaut Syndrome 
Authors
 김신혜  ;  김성현  ;  이윤진  ;  이영목  ;  이준수  ;  김동석  ;  김흥동 
Citation
 Journal of Korean Epilepsy Society (대한간질학회지), Vol.12(1) : 41-45, 2008 
Journal Title
 Journal of Korean Epilepsy Society (대한간질학회지) 
ISSN
 1226-6965 
Issue Date
2008
Keywords
Lennox-Gastaut syndrome ; Corpus callosotomy ; Seizure outcome
Abstract
Purpose: Lennox-Gastaut syndrome (LGS) is one of the most devastating pediatric epileptic syndromes characterized by various disabling seizures, generalized forms of abnormal epileptiform EEG features and progressive psychomotor retardation. Corpus callosotomy is one of treatment options in patients with intractable LGS without definitive focal cortical pathology. This study was designed to evaluate efficacy and safety of corpus callosotomy in patients with LGS. Patients and Methods: Thirty patients (21 boys, 9 girls) with LGS who had corpus callosotomy at Severance Children’s Hospital from October 2003 to January 2007, were enrolled with mean followup of 34.6±14.0 months. We retrospectively reviewed medical records, video-EEG monitoring, MRI, seizure outcome and postoperative complications. Results: Mean age of corpus callosotomy was 100.7±56.4 months. Twenty-four patient (80.0%) underwent total corpus callosotomy and 6 (20.0%) underwent resection of the anterior 4/5 of corpus callosum. Seizure outcomes were as follows: 5 patients (16.7%) were Engel class I, 9 (30.0%) were class II, 6 (20.0%) were class III and 10 (33.3%) were class IV. Postoperative complications were seen in 4 patients (13.3%), such as hemorrhage (2 patients), involuntary movement (1 patient) and transient ataxia (1 patient), but all were recovered completely. Subsequent resective surgery was performed in 5 patients of Engel class III and IV, whose EEG features became lateralized without complete seizure control. Satisfactory surgical outcomes (class I and II) were achieved in 46.7% of total patients. Conclusions: Corpus callosotomy could be effective and safe treatment in medically intractable LGS without focal pathology
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Young Mock(이영목) ORCID logo https://orcid.org/0000-0002-5838-249X
Lee, Yun Jin(이윤진)
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107258
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