0 313

Cited 18 times in

ACE I/D polymorphism in Korean patients with ischemic stroke and silent brain infarction

Authors
 Hong SH  ;  Park HM  ;  Ahn JY  ;  Kim OJ  ;  Hwang TS  ;  Oh D  ;  Kim NK. 
Citation
 ACTA NEUROLOGICA SCANDINAVICA, Vol.117(4) : 244-249, 2008 
Journal Title
 ACTA NEUROLOGICA SCANDINAVICA 
ISSN
 0001-6314 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Brain Infarction/enzymology* ; Brain Infarction/ethnology ; Brain Infarction/genetics* ; Brain Ischemia/enzymology* ; Brain Ischemia/ethnology ; Brain Ischemia/genetics* ; Cerebral Arteries/enzymology ; Cerebral Arteries/physiopathology ; DNA Mutational Analysis ; Female ; Genetic Markers/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Testing ; Genotype ; Humans ; Korea ; Male ; Middle Aged ; Peptidyl-Dipeptidase A/genetics* ; Polymorphism, Genetic/genetics*
Keywords
ACEpolymorphism ; ischemic stroke ; silentbrain infarction
Abstract
OBJECTIVES: Angiotensin-converting enzyme (ACE) polymorphism may play a role in stroke and silent brain infarction (SBI) susceptibility, but the results among the populations studied to date have not been consistent. Thus, we investigated the association between ACE genotypes and ischemic stroke and SBI in Korean patients. SUBJECTS AND METHODS: DNA samples from 237 stroke patients, 264 SBI patients and 234 age-matched controls were amplified using polymerase chain reaction to detect the ACE ins/del (I/D) polymorphism. Genotype was determined by the presence of a 490-bp band (I allele) or a 190-bp band (D allele) in agarose gel electrophoresis. RESULTS: Odds ratios of the I/D and D/D genotypes and the overall (I/D + D/D) for the I/I genotype were significantly different between stroke patients and normal controls. However, there was no significant difference between patients with SBI and controls. CONCLUSIONS: This study is the first report of a significant association between ACE polymorphism and ischemic stroke in the Asian population. Although no consistent associations have been found between ACE polymorphism and stroke in the populations studied to date, the ACE polymorphism may be a genetic determinant of ischemic stroke, at least in Korean patients.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.2007.00932.x/abstract
DOI
10.1111/j.1600-0404.2007.00932.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jung Yong(안정용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107216
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse