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간경변증 환자에서 간정맥 압력차와 간경변증의 임상 병기, 정맥류 및 복수와의 상관관계

Other Titles
 Measurement of hepatic venous pressure gradient in liver cirrhosis: Relationship with the status of cirrhosis, varices, and ascites in Korea 
Authors
 김문영  ;  백순구  ;  석기태  ;  예창진  ;  이일영  ;  김재우  ;  차승환  ;  김영주  ;  엄순호  ;  한광협 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.14(2) : 150-158, 2008 
Journal Title
Korean Journal of Hepatology(대한간학회지)
ISSN
 1226-0479 
Issue Date
2008
Keywords
Hepatic venous pressure gradient ; Hypertension ; Portal ; Child-Pugh score ; MELD score
Abstract
Background/Aims: The relationships between the hepatic venous pressure gradient (HVPG) and the status of cirrhosis, complications of portal hypertension and the severity of cirrhosis are not clear. The aim of this study was to determine the relationships between HVPG and the complications or status of cirrhosis. Methods: The HVPG, gastroesophageal varices, Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, presence of ascites, recent bleeding history and the status of cirrhosis were assessed in a cohort of 172 patients (156 males, 16 females) with liver cirrhosis. Results: The HVPG was 15.6±5.1 (mean± SD) mmHg (4-33 mmHg) and was significantly higher in patients in the decompensated stage than in those in the compensated stage (16.6±4.3 vs. 10.8±6.1 mmHg, respectively; P<0.01). HVPG was higher in bleeders than in nonbleeders (16.9±4.5 vs. 12.8±5.3 mmHg, respectively; P<0.01), and in patients with ascites than in those without ascites (16.4±4.1 vs. 14.5±6.2 mmHg, respectively; P<0.05). HVPG was significantly lower in the presence of gastric varices than in their absence (14.0±3.4 vs. 16.0±5.3 mmHg, respectively; P<0.05); however, no significant correlation was detected between HVPG and the grade of esophageal varices (P>0.05). HVPG was significantly higher in Child’s B cirrhosis (n=87, 15.6±4.7 mmHg) and Child’s C cirrhosis (n=36, 18.4±4.7 mmHg) than in Child’s A cirrhosis (n=49, 13.7±5.1 mmHg; P<0.01). HVPG also was strongly correlated with the MELD score (P<0.01). The time required to measure the HVPG was 11.2±6.4 min, and only three cases of minor complication occurred during the procedure. Conclusions: HVPG was correlated with the severity of liver cirrhosis, presence of ascites, and risk of variceal bleeding in patients with liver cirrhosis.
Files in This Item:
T200800924.pdf Download
DOI
10.3350/kjhep.2008.14.2.150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107193
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