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Telomeric 3' overhangs in chronic HBV-related hepatitis and hepatocellular carcinoma

DC Field Value Language
dc.contributor.author박영년-
dc.contributor.author오봉경-
dc.contributor.author최진섭-
dc.date.accessioned2015-05-19T16:53:28Z-
dc.date.available2015-05-19T16:53:28Z-
dc.date.issued2008-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/107133-
dc.description.abstractTelomeric 3' overhang is a key component of telomere structure, but little is known about its role in hepatocarcinogenesis. We examined the 3' overhang and telomere length, mRNA levels of hTERT, POT1, TRF1 and cytokeratin 19 (CK19) in 41 hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) and adjacent non-HCCs of B viral chronic hepatitis/cirrhosis. 3' overhang length was positively correlated with telomere length (p < 0.001). In non-HCCs, the 3' overhang shortened with increasing age (p = 0.043). Twenty-six HCCs had shorter and 15 HCCs had longer 3' overhangs than the adjacent non-HCCs. The mRNA levels of hTERT, POT1 and TRF1 were upregulated in HCCs than in non-HCCs. HCCs with lengthened 3' overhangs expressed higher hTERT mRNA levels than those with shortened 3' overhangs, when compared to 3' overhangs in non-HCCs (p = 0.044). POT1 and TRF1 showed no significant difference according to the 3' overhangs. HCCs with long 3' overhangs had higher mitosis (p = 0.046) and more frequent multipolar mitosis compared to those with short 3' overhangs (p = 0.034). HCCs with high cytokeratin 19 mRNA levels, a marker for hepatic progenitor cells, had longer 3' overhangs than HCCs with low cytokeratin 19 mRNA levels (p= 0.019). In conclusion, the 3' overhang erosion might be closely related to the number of cell divisions in telomerase-negative hepatocytes of chronic hepatitis/cirrhosis. In telomerase-positive HCCs, an altered 3' overhang are involved in HBV-related hepatocarcinogenesis and hTERT might be involved in regulation of 3' overhang-
dc.description.statementOfResponsibilityopen-
dc.format.extent264~272-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/enzymology-
dc.subject.MESHCarcinoma, Hepatocellular/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHKeratin-19/analysis-
dc.subject.MESHLiver Cirrhosis/genetics-
dc.subject.MESHLiver Neoplasms/enzymology-
dc.subject.MESHLiver Neoplasms/genetics*-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHTelomerase/analysis*-
dc.subject.MESHTelomerase/genetics-
dc.subject.MESHTelomere*-
dc.subject.MESHTelomere-Binding Proteins/analysis-
dc.subject.MESHTelomeric Repeat Binding Protein 1/analysis-
dc.titleTelomeric 3' overhangs in chronic HBV-related hepatitis and hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJae-Eun Lee-
dc.contributor.googleauthorBong-Kyeong Oh-
dc.contributor.googleauthorJinsub Choi-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1002/ijc.23376-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01563-
dc.contributor.localIdA02369-
dc.contributor.localIdA04199-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid18449889-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.23376/abstract-
dc.subject.keywordtelomeric 30overhang-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordtelomere-
dc.subject.keywordhTERT-
dc.subject.keywordcytokeratin 19-
dc.subject.keywordhepatitis B virus-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameOh, Bong Kyeong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorOh, Bong Kyeong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.rights.accessRightsnot free-
dc.citation.volume123-
dc.citation.number2-
dc.citation.startPage264-
dc.citation.endPage272-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.123(2) : 264-272, 2008-
dc.identifier.rimsid46009-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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