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Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans

Authors
 VANESSA L. CROPLEY  ;  ROBERT B. INNIS  ;  PRADEEP J. NATHAN  ;  AMIRA K. BROWN  ;  JANET L. SANGARE  ;  ALICJA LERNER  ;  YONG HOON RYU  ;  KELLY E. SPRAGUE  ;  VICTOR W. PIKE  ;  MASAHIRO FUJITA 
Citation
 SYNAPSE, Vol.62(6) : 399-408, 2008 
Journal Title
SYNAPSE
ISSN
 0887-4476 
Issue Date
2008
MeSH
D 2 radioligand ; D‐amphetamine ; α‐methyl‐ para‐tyrosine ; phasic tonic ; PET
Keywords
Administration, Oral ; Adult ; Amphetamine/administration & dosage ; Analysis of Variance ; Benzamides/metabolism* ; Binding, Competitive/drug effects ; Brain/diagnostic imaging* ; Brain/drug effects ; Brain Mapping* ; Dopamine/metabolism* ; Dopamine Uptake Inhibitors/administration & dosage ; Enzyme Inhibitors/administration & dosage ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Positron-Emission Tomography/methods ; Pyrrolidines/metabolism* ; Reproducibility of Results ; alpha-Methyltyrosine/administration & dosage
Abstract
Molecular imaging has been used to estimate both drug-induced and tonic dopamine release in the striatum and most recently extrastriatal areas of healthy humans. However, to date, studies of drug-induced and tonic dopamine release have not been performed in the same subjects. This study performed positron emission tomography (PET) with [18F]fallypride in healthy subjects to assess (1) the reproducibility of [18F]fallypride and (2) both D-amphetamine-induced and alpha-methyl-p-tyrosine (AMPT)-induced changes in dopamin release on [(18)F]fallypride binding in striatal and extrastriatal areas. Subjects underwent [18F]fallypride PET studies at baseline and following oral D-amphetamine administration (0.5 mg/kg) and oral AMPT administration (3 g/70 kg/day over 44 h). Binding potential (BP) (BP(ND)) of [18F]fallypride was calculated in striatal and extrastriatal areas using a reference region method. Percent change in regional BP(ND) was computed and correlated with change in cognition and mood. Test-retest variability of [18F]fallypride was low in both striatal and extrastriatal regions. D-Amphetamine significantly decreased BP(ND) by 8-14% in striatal subdivisions, caudate, putamen, substantia nigra, medial orbitofrontal cortex, and medial temporal cortex. Correlation between change in BP(ND) and verbal fluency was seen in the thalamus and substantia nigra. In contrast, depletion of endogenous dopamine with AMPT did not effect [18F]fallypride BP(ND) in both striatum and extrastriatal regions. These findings indicate that [18F]fallypride is useful for measuring amphetamine-induced dopamine release, but may be unreliable for estimating tonic dopamine levels, in striatum and extrastriatal regions of healthy humans.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/syn.20506/abstract
DOI
10.1002/syn.20506
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107047
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