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단일 3차 의료기관에서 수집한 약물 유해반응의 양상 분석

Other Titles
 Clinical Features of Adverse Drug Reactions in a Tertiary Care Hospital in Korea 
 김명현  ;  정한영  ;  손명균  ;  김성은  ;  이용원  ;  박중원  ;  홍천수 
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.28(1) : 35-39, 2008 
Journal Title
Journal of Asthma, Allergy and Clinical Immunology(천식 및 알레르기)
Issue Date
Adverse drug reaction ; NSAID ; Radiocontrast media
Background: Clinical features of adverse drug reactions (ADR) are different and the incidence is increasing. However, there have been only a few data on the clinical features of ADR in Korea. Method: We prospectively collected ADR cases at Severance Hospital between October 2003 and April 2006, analyzed the clinical features. Result: Three hundred and fifty-seven ADR cases were reported. The most common causative drugs were radiocontrast media and nonsteroidal anti-inflammatory drugs (NSAIDs), followed by anticonvulsants, such as lamotrigine, carbamazepine, theophyllines and cephalosporins. Most of the causative radiocontrast media were nonionic, low molecular and iodinated. The leading clinical features were skin eruptions and urticaria. Nine cases of serious ADR were induced by general medication, including 1 case of mortality due to allopurinol-induced toxic epidermal necrolysis. ADR cases induced by contrast media were 245. Conclusion: The most common causative drugs which induced adverse drug reactions were NSAIDs and radiocontrast media. The leading clinical features were skin eruptions and urticaria. Among radiocontrast media, nonionic low molecular iodinated contrast media mainly induced adverse drug reactions. Further epidemiologic studies will validate our study and help reveal the incidence of ADR in Korea
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Son, Myoung Kyun(손명균)
Lee, Yong Won(이용원)
Hong, Chein Soo(홍천수)
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