271 150

Cited 0 times in

천식경과 중 메타콜린 검사 음성화 전환 환자군의 임상적 특성

Other Titles
 Clinical Characteristics of Bronchial Asthmatics Who Showed Negative Conversion of Airway Hyperreactivity in the Methacholine Provocation Test 
Authors
 박세미  ;  이용원  ;  박중원  ;  홍천수 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.28(1) : 20-25, 2008 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology  (천식 및 알레르기) 
ISSN
 1226-8739 
Issue Date
2008
Abstract
Background: Clinical characteristics of asthmatics undergoing negative conversion of bronchial hyperreactivity in the methacholine bronchial provocation test (M-test) were not completely evaluated yet. We investigated clinical characteristics of negative conversion of bronchial hyperreactivity in asthmatics. Method: We enrolled 57 patients who were treated more than 1 year at our clinic. We compared parameters of clinical data and the PC20 results of the pulmonary function test and M-test between the negative conversion group (NCG) of bronchial hyperreactivity and the control group with persistent bronchial hyperreactivity (CG). Result: Thirty of the 57 asthmatics showed negative conversion of bronchial hyperreactivity in the M-tests and included in NCG. The remaining 27 patients were included in the CG. There were no significant differences in sex, age, smoking history, atopic sensitization and the initial severity of asthma between the NCG and CG. The initial PC20 of the CG (1.31±2.03 mg/mL) was not significantly different from that of NCG (2.34±4.36 mg/mL) either. The mean treatment duration until negative conversion of bronchial hyperreactivity was 5.46±4.28 years. The initial TEC of the NCG (399.29±250.66 /mcL) was lower than that of the CG (608.92±371.74 /mcL)(P=0.018). Eosinophils in induced sputum (%) of the NCG (22.23±21.63%) was also lower than that of the CG (40.85±32.07%)(P=0.021). The initial FEV1 was higher in the NCG (86.06±15.96%) than in the CG (72.37±18.40%)(p=0.004). FEV1/FVC was also higher in the NCG (76.54±9.59%) than in the CG (65.43±11.14)(P<0.001). QOL scores were not significantly different between both groups. Conclusion: The negative conversion group of bronchial hyperreactivity may show better pulmonary functions and milder eosinophilic inflammation
Files in This Item:
T200800771.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Se Mi(박세미)
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Yong Won(이용원)
Hong, Chein Soo(홍천수)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107037
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse