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PMMA (polymethylmetacrylate) microspheres and stabilized hyaluronic acid as an injection laryngoplasty material for the treatment of glottal insufficiency: in vivo canine study

Authors
 Jae-Yol Lim  ;  Han Su Kim  ;  Young-Ho Kim  ;  Kwang-Moon Kim  ;  Hong-Shik Choi 
Citation
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.265(3) : 321-326, 2008 
Journal Title
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 
ISSN
 0937-4477 
Issue Date
2008
MeSH
Animals ; Biocompatible Materials/administration & dosage* ; Collagen/administration & dosage* ; Disease Models, Animal ; Dogs ; Female ; Foreign-Body Reaction/epidemiology ; Hyaluronic Acid/administration & dosage ; Hyaluronic Acid/analogs & derivatives* ; Injections ; Male ; Microspheres ; Polymethyl Methacrylate/administration & dosage ; Prostheses and Implants* ; Vocal Cord Paralysis/therapy*
Keywords
Microspheres ; Hyaluronic acid ; Injection laryngoplasty ; Glottal insufficiency
Abstract
Both PMMA (polymethylmetacrylate) microspheres (PM) and stabilized hyaluronic acid (HA) are recently used for facial augmentation. The aim of this study was to test functional effect, durability, and safety of the injection of these two materials into true vocal folds, and test their availability as injection laryngoplasty materials in vivo canine model. The study was carried out with 16 beagle dogs (8 males and 8 females, average weight of 12.4 kg). No biological difference was detected between two groups; PM (Artecoll) injection and HA (Restylane) injection group. After inducing complete unilateral paralysis of the recurrent laryngeal nerve of the dogs, either PM or HA was injected into the paralyzed vocal fold. One, 3, 6, and 9 months after the injection, clinical outcomes and videostroboscopic findings were evaluated by investigators who were blind to the injection materials. Histological study and microscopic computerized augmentation dimension analysis were also performed. In HA injection group, up to 30% the HA was gradually resorbed over time. However, in PM group, the dimension of the augmented region after 9 months was similar to that after 1 month. In both groups, the mucosal waves of the vocal folds decreased in amplitude and periodicity, but they were still well detected during the follow-up periods. Acute immune reaction to HA was not detected, but some degree of foreign body reaction occurred in PM injection group. Both PM and HA are safe and relatively durable in vocal folds and they are considered as useful candidates for injection laryngoplasty
Full Text
http://link.springer.com/article/10.1007%2Fs00405-007-0458-y
DOI
10.1007/s00405-007-0458-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Moon(김광문)
Kim, Young Ho(김영호)
Kim, Han Su(김한수)
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Choi, Hong Shik(최홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106855
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