크론병 환자에서 Trichuris suis ova 치험 1예

Abstract

Crohn's disease (CD) is one of the chronic inflammatory bowel diseases of unknown etiology. It may develop in any part of the gastrointestinal tract, with periods of remission and relapse of symptoms. The incidence of CD has increased rapidly during the past several decades. CD is generally treated with 5-aminosalicylic acid, steroids, immunomodulators such as azathioprine, and the monoclonal antibody for TNF-α known as infliximab. Patients with CD demonstrate immune dysregulation and excessive Th1 inflammatory response. Helminths induce strong Th2 immune responses that can inhibit or down-regulate the host Th1 immune response to unrelated, concomitant parasitic, bacterial, and viral infections. This response may be beneficial in CD, since recent studies have reported that Trichuris suis ova can be used as a therapeutic agent for CD. Trichuris suis is a porcine whipworm genetically related to Trichuris trichiura, the human whipworm. We report a therapeutic experience using Trichuris suis ova in a patient with CD.