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MicroRNA expression profiles in serous ovarian carcinoma

Authors
 Eun Ji Nam  ;  Heejei Yoon  ;  Sang Wun Kim  ;  Hoguen Kim  ;  Young Tae Kim  ;  Jae Hoon Kim  ;  Jae Wook Kim  ;  Sunghoon Kim 
Citation
 CLINICAL CANCER RESEARCH, Vol.14(9) : 2690-2695, 2008 
Journal Title
 CLINICAL CANCER RESEARCH 
ISSN
 1078-0432 
Issue Date
2008
MeSH
Cystadenocarcinoma, Serous/genetics* ; Cystadenocarcinoma, Serous/metabolism ; Cystadenocarcinoma, Serous/mortality ; Female ; Gene Expression Profiling ; Humans ; Kaplan-Meier Estimate ; MicroRNAs/genetics ; MicroRNAs/metabolism* ; Oligonucleotide Array Sequence Analysis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Ovary/metabolism* ; Prognosis
Keywords
Cystadenocarcinoma, Serous/genetics* ; Cystadenocarcinoma, Serous/metabolism ; Cystadenocarcinoma, Serous/mortality ; Female ; Gene Expression Profiling ; Humans ; Kaplan-Meier Estimate ; MicroRNAs/genetics ; MicroRNAs/metabolism* ; Oligonucleotide Array Sequence Analysis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/mortality ; Ovary/metabolism* ; Prognosis
Abstract
PURPOSE: Although microRNAs have recently been recognized as riboregulators of gene expression, little is known about microRNA expression profiles in serous ovarian carcinoma. We assessed the expression of microRNA and the association between microRNA expression and the prognosis of serous ovarian carcinoma. EXPERIMENTAL DESIGN: Twenty patients diagnosed with serous ovarian carcinoma and eight patients treated for benign uterine disease between December 2000 and September 2003 were enrolled in this study. The microRNA expression profiles were examined using DNA microarray and Northern blot analyses. RESULTS: Several microRNAs were differentially expressed in serous ovarian carcinoma compared with normal ovarian tissues, including miR-21, miR-125a, miR-125b, miR-100, miR-145, miR-16, and miR-99a, which were each differentially expressed in >16 patients. In addition, the expression levels of some microRNAs were correlated with the survival in patients with serous ovarian carcinoma. Higher expression of miR-200, miR-141, miR-18a, miR-93, and miR-429, and lower expression of let-7b, and miR-199a were significantly correlated with a poor prognosis (P < 0.05). CONCLUSION: Our results indicate that dysregulation of microRNAs is involved in ovarian carcinogenesis and associated with the prognosis of serous ovarian carcinoma.
Files in This Item:
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DOI
10.1158/1078-0432.CCR-07-1731
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Kim, Ho Keun(김호근)
Nam, Eun Ji(남은지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106756
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