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Rosiglitazone inhibits early stage of glucolipotoxicity-induced beta-cell apoptosis
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김소헌 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 윤채옥 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 한승진 | - |
dc.contributor.author | 허규연 | - |
dc.date.accessioned | 2015-05-19T16:40:33Z | - |
dc.date.available | 2015-05-19T16:40:33Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0301-0163 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106736 | - |
dc.description.abstract | AIM: We investigated whether rosiglitazone protects beta-cells from glucolipotoxicity directly. METHODS: INS-1 cells were incubated with 25 mM glucose and 0.5 mM palmitate in the absence or presence of 2.5 microM rosiglitazone. We evaluated caspase-3 expression and nuclear DAPI staining. An in vivo study was performed, in which 18-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were treated with rosiglitazone (4 mg/kg/day, n = 6) and with placebo (n = 6) for 10 weeks. At 28 weeks of age, an oral glucose tolerance test, insulin sensitivity test, TUNEL assay and histologic examination were performed. RESULTS: Rosiglitazone attenuated glucolipotoxicity-induced nuclear change and caspase-3 expression for 8 h after treatment, but this effect was not observed at 12 h in INS-1 cells. Rosiglitazone treatment decreased beta-cell apoptosis, preserved beta-cell mass and improved glucose tolerance in OLETF rats. CONCLUSION: The present in vitro findings suggest that rosiglitazone can inhibit the early stage of glucolipotoxicity-induced beta-cell apoptosis. Our results suggest that the antidiabetic action of rosiglitazone is, at least in part, related to a direct effect on beta-cells rather than simply an indirect effect of improving insulin sensitivity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 165~173 | - |
dc.relation.isPartOf | Hormone Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Caspase 3/biosynthesis | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cholesterol/blood | - |
dc.subject.MESH | DNA Damage | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/pathology* | - |
dc.subject.MESH | Fatty Acids, Nonesterified/blood | - |
dc.subject.MESH | Glucose/pharmacology | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Hypoglycemic Agents/pharmacology* | - |
dc.subject.MESH | Immunoblotting | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Insulin/blood | - |
dc.subject.MESH | Insulin-Secreting Cells/drug effects* | - |
dc.subject.MESH | Insulin-Secreting Cells/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Palmitates/pharmacology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred OLETF | - |
dc.subject.MESH | Thiazolidinediones/pharmacology* | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Rosiglitazone inhibits early stage of glucolipotoxicity-induced beta-cell apoptosis | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Cancer Research (암연구소) | - |
dc.contributor.googleauthor | Seung Jin Han | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Kyu Yeon Hur | - |
dc.contributor.googleauthor | Hae Jin Kim | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.contributor.googleauthor | Chae-Ok Yun | - |
dc.contributor.googleauthor | Sung-E Choi | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Yup Kang | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.1159/000137662 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00624 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A02614 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04302 | - |
dc.contributor.localId | A04343 | - |
dc.relation.journalcode | J01000 | - |
dc.identifier.pmid | 18663317 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/137662 | - |
dc.subject.keyword | Glucolipotoxicity | - |
dc.subject.keyword | Rosiglitazone | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, So Hun | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Yun, Chae Ok | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Han, Seung Jin | - |
dc.contributor.alternativeName | Hur, Kyu Yeon | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, So Hun | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Han, Seung Jin | - |
dc.contributor.affiliatedAuthor | Hur, Kyu Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 70 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 173 | - |
dc.identifier.bibliographicCitation | Hormone Research, Vol.70(3) : 165-173, 2008 | - |
dc.identifier.rimsid | 49334 | - |
dc.type.rims | ART | - |
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