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Adiponectin gene polymorphism 45T>G is associated with carotid artery plaques in patients with type 2 diabetes mellitus

Authors
 So Hun Kim  ;  Eun Seok Kang  ;  Kyu Yeon Hur  ;  Hyun Joo Lee  ;  Seung Jin Han  ;  Jung Young Kwak  ;  Chung Mo Nam  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Hyun Chul Lee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.57(2) : 274-279, 2008 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2008
MeSH
Adiponectin/genetics* ; Carotid Artery Diseases/complications* ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/genetics* ; Carotid Artery Diseases/pathology ; Carotid Artery, Common/diagnostic imaging ; Carotid Artery, Common/pathology* ; DNA/chemistry ; DNA/genetics ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/genetics* ; Diabetes Mellitus, Type 2/pathology ; Female ; Genotype ; Humans ; Linear Models ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Ultrasonography
Keywords
Adiponectin/genetics* ; Carotid Artery Diseases/complications* ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/genetics* ; Carotid Artery Diseases/pathology ; Carotid Artery, Common/diagnostic imaging ; Carotid Artery, Common/pathology* ; DNA/chemistry ; DNA/genetics ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/genetics* ; Diabetes Mellitus, Type 2/pathology ; Female ; Genotype ; Humans ; Linear Models ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Ultrasonography
Abstract
Adiponectin has been reported to have a wide range of antiatherogenic actions. Two common single nucleotide polymorphisms (SNPs) at the adiponectin locus (45T>G and 276G>T) have been reported to be associated with diabetes and cardiovascular diseases. The aim of this study was to examine the association between common polymorphisms of the adiponectin gene (ACDC) and carotid atherosclerosis in patients with type 2 diabetes mellitus. A total of 708 unrelated patients with type 2 diabetes mellitus were recruited. SNP45 and SNP276 ACDC were genotyped, and B-mode ultrasonography of the carotid arteries was performed to measure carotid intima-media thickness and assess the presence of carotid artery plaques (CAP). Although there was no significant difference in carotid intima-media thickness according to ACDC genotype, subjects carrying the SNP45 GG genotype had a significantly higher risk of having CAP (odds ratio, 2.468; P = .045) compared with carriers of the T allele after adjustment for possible confounding factors. This study suggests that the GG genotype at ACDC SNP45 is associated with the presence of CAP and may contribute to atherosclerosis in type 2 diabetes mellitus.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049507003320
DOI
10.1016/j.metabol.2007.09.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Joo(이현주)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Seung Jin(한승진)
Hur, Kyu Yeon(허규연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106722
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