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A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma

 Hai-Jin Kim  ;  Jong-Suk Park  ;  Chul-Sik Kim  ;  Eun-Seok Kang  ;  Bong-Soo Cha  ;  Sung-Kil Lim  ;  Kyung-Rae Kim  ;  Hyun-Chul Lee  ;  Chul-Woo Ahn 
 Yonsei Medical Journal, Vol.49(3) : 503-506, 2008 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/pathology* ; Diagnosis, Differential ; Female ; Humans ; Multiple Endocrine Neoplasia Type 1/genetics ; Multiple Endocrine Neoplasia Type 1/pathology* ; Mutation ; Proto-Oncogene Proteins/genetics ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology*
Multiple endocrine neoplasia type 1 ; papillary thyroid carcinoma ; prolactinoma ; gastrinoma ; parathyroid hyperplasia
This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN1) in Korea. MEN1 is a hereditary disease comprising neoplastic disorders such as pituitary, parathyroid and pancreatic neuroendocrine tumor, such as gastrinoma. But papillary thyroid cancer was never regarded as its component before in Korea. Herein we present a 39-year-old woman who manifested typical features of MEN1 with a coincidental papillary thyroid carcinoma. Although the family history of MEN1 was definite, her genetic analysis of DNA had revealed no germline mutation in MEN1 gene locus. Unidentified culprit gene unable us further genetic study to find LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN1. As we have first experienced a case of MEN1 combined with papillary thyroid carcinoma in Korea, we report it with the review of literature.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Kim, Chul Sik(김철식)
Kim, Hae Jin(김혜진)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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