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A case of multiple endocrine neoplasia type 1 combined with papillary thyroid carcinoma

 Hai-Jin Kim  ;  Jong-Suk Park  ;  Chul-Sik Kim  ;  Eun-Seok Kang  ;  Bong-Soo Cha  ;  Sung-Kil Lim  ;  Kyung-Rae Kim  ;  Hyun-Chul Lee  ;  Chul-Woo Ahn 
 Yonsei Medical Journal, Vol.49(3) : 503-506, 2008 
Journal Title
 Yonsei Medical Journal 
Issue Date
This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN1) in Korea. MEN1 is a hereditary disease comprising neoplastic disorders such as pituitary, parathyroid and pancreatic neuroendocrine tumor, such as gastrinoma. But papillary thyroid cancer was never regarded as its component before in Korea. Herein we present a 39-year-old woman who manifested typical features of MEN1 with a coincidental papillary thyroid carcinoma. Although the family history of MEN1 was definite, her genetic analysis of DNA had revealed no germline mutation in MEN1 gene locus. Unidentified culprit gene unable us further genetic study to find LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN1. As we have first experienced a case of MEN1 combined with papillary thyroid carcinoma in Korea, we report it with the review of literature.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김경래(Kim, Kyung Rae)
김철식(Kim, Chul Sik)
김혜진(Kim, Hae Jin)
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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