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OLETF쥐에서 Amlodipine, Losartan과 비교한 Lithospermic Acid B의 당뇨병성 신증 예방효과

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김범석-
dc.contributor.author김철훈-
dc.contributor.author안철우-
dc.contributor.author이현철-
dc.contributor.author전성완-
dc.contributor.author차봉수-
dc.contributor.author하헌주-
dc.contributor.author한승진-
dc.contributor.author허규연-
dc.date.accessioned2015-05-19T16:38:44Z-
dc.date.available2015-05-19T16:38:44Z-
dc.date.issued2008-
dc.identifier.issn1976-9180-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106682-
dc.description.abstractBACKGROUND: Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. METHODS: LAB (20 mg/kg), amlodipine (10 mg/kg), or losartan (10 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. RESULTS: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. Treatment with amlodipine or losartan resulted in similar reductions in blood pressure; however, LAB was less effective in lowering blood pressure. Albuminuria was markedly suppressed by losartan and LAB, but not by amlodipine. LAB treatment decreased levels of renal lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta1 (TGF-beta1). CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan-
dc.description.statementOfResponsibilityopen-
dc.format.extent10~20-
dc.relation.isPartOfKorean Diabetes Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOLETF쥐에서 Amlodipine, Losartan과 비교한 Lithospermic Acid B의 당뇨병성 신증 예방효과-
dc.title.alternativeProtective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthor강은석-
dc.contributor.googleauthor김범석-
dc.contributor.googleauthor김철훈-
dc.contributor.googleauthor서기호-
dc.contributor.googleauthor한승진-
dc.contributor.googleauthor전성완-
dc.contributor.googleauthor허규연-
dc.contributor.googleauthor안철우-
dc.contributor.googleauthor하헌주-
dc.contributor.googleauthor정만길-
dc.contributor.googleauthor차봉수-
dc.contributor.googleauthor이현철-
dc.identifier.doi10.4093/kdj.2008.32.1.10-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA00488-
dc.contributor.localIdA01057-
dc.contributor.localIdA02270-
dc.contributor.localIdA03301-
dc.contributor.localIdA03519-
dc.contributor.localIdA03996-
dc.contributor.localIdA04262-
dc.contributor.localIdA04302-
dc.contributor.localIdA04343-
dc.relation.journalcodeJ01955-
dc.identifier.pmidLithospermic acid B , Amlodipine , Losartan , OLETF rats , Diabetic nephropathy-
dc.subject.keywordLithospermic acid B , Amlodipine , Losartan , OLETF rats , Diabetic nephropathy-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameChun, Sung Wan-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHa, Hun Joo-
dc.contributor.alternativeNameHan, Seung Jin-
dc.contributor.alternativeNameHur, Kyu Yeon-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorChun, Sung Wan-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHa, Hun Joo-
dc.contributor.affiliatedAuthorHan, Seung Jin-
dc.contributor.affiliatedAuthorHur, Kyu Yeon-
dc.rights.accessRightsfree-
dc.citation.volume32-
dc.citation.number1-
dc.citation.startPage10-
dc.citation.endPage20-
dc.identifier.bibliographicCitationKorean Diabetes Journal, Vol.32(1) : 10-20, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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