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Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development

DC Field Value Language
dc.contributor.author이종민-
dc.contributor.author정한성-
dc.contributor.author조경원-
dc.contributor.author조성원-
dc.contributor.author김재영-
dc.contributor.author이민정-
dc.date.accessioned2015-05-19T16:38:21Z-
dc.date.available2015-05-19T16:38:21Z-
dc.date.issued2008-
dc.identifier.issn0012-1606-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106671-
dc.description.abstractVarious cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent341~350-
dc.relation.isPartOfDEVELOPMENTAL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAging/physiology-
dc.subject.MESHAnimals-
dc.subject.MESHElectroporation-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHMaxilla/cytology-
dc.subject.MESHMaxilla/growth & development-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHOrgan Culture Techniques-
dc.subject.MESHPalate/cytology*-
dc.subject.MESHPalate/growth & development-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHRNA, Small Interfering/genetics-
dc.subject.MESHReceptor Cross-Talk/physiology-
dc.subject.MESHReceptor, Fibroblast Growth Factor, Type 1/genetics-
dc.subject.MESHReceptor, Fibroblast Growth Factor, Type 1/physiology*-
dc.subject.MESHWnt Proteins/genetics-
dc.subject.MESHWnt Proteins/physiology*-
dc.titleWnt11/Fgfr1b cross-talk modulates the fate of cells in palate development-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorJae-Young Kim-
dc.contributor.googleauthorKyoung-Won Cho-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorSungwook Kwak-
dc.contributor.googleauthorJinglei Cai-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1016/j.ydbio.2007.11.033-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03758-
dc.contributor.localIdA03802-
dc.contributor.localIdA03837-
dc.contributor.localIdA00862-
dc.contributor.localIdA02785-
dc.contributor.localIdA04640-
dc.relation.journalcodeJ00713-
dc.identifier.eissn1095-564X-
dc.identifier.pmid18191119-
dc.subject.keywordWnt11-
dc.subject.keywordFgfr1b-
dc.subject.keywordPalatogenesis-
dc.subject.keywordPalatal growth-
dc.subject.keywordPalatal fusion-
dc.subject.keywordCell proliferation-
dc.subject.keywordApoptosis-
dc.subject.keywordz-VAD-fmk-
dc.subject.keywordWnt11 siRNA-
dc.contributor.alternativeNameLee, Jong Min-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Kyoung Won-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.alternativeNameKim, Jae Young-
dc.contributor.alternativeNameLee, Min Jung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Kyoung Won-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorKim, Jae Young-
dc.contributor.affiliatedAuthorLee, Min Jung-
dc.contributor.affiliatedAuthorLee, Jong Min-
dc.rights.accessRightsfree-
dc.citation.volume314-
dc.citation.number2-
dc.citation.startPage341-
dc.citation.endPage350-
dc.identifier.bibliographicCitationDEVELOPMENTAL BIOLOGY, Vol.314(2) : 341-350, 2008-
dc.identifier.rimsid46648-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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