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Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author박은성-
dc.contributor.author천재희-
dc.date.accessioned2015-05-19T16:37:56Z-
dc.date.available2015-05-19T16:37:56Z-
dc.date.issued2008-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106659-
dc.description.abstractPURPOSE: The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate of recurrence even after "curative resection" of tumors. Therefore, it is axiomatic that the development of an effective prognostic prediction model for HCC recurrence after surgery would, at minimum, help to identify in advance those who would most benefit from the treatment, and at best, provide new therapeutic strategies for patients with a high risk of early recurrence. EXPERIMENTAL DESIGN: For the prediction of the recurrence time in patients with HCC, gene expression profiles were generated in 65 HCC patients with hepatitis B infections. RESULT: Recurrence-associated gene expression signatures successfully discriminated between patients at high-risk and low-risk of early recurrence (P=1.9 x 10(-6), log-rank test). To test the consistency and robustness of the recurrence signature, we validated its prognostic power in an independent HCC microarray data set. CD24 was identified as a putative biomarker for the prediction of early recurrence. Genetic network analysis suggested that SP1 and peroxisome proliferator-activated receptor-alpha might have regulatory roles for the early recurrence of HCC. CONCLUSION: We have identified a gene expression signature that effectively predicted early recurrence of HCC independent of microarray platforms and cohorts, and provided novel biological insights into the mechanisms of tumor recurrence-
dc.description.statementOfResponsibilityopen-
dc.format.extent2056~2064-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHGene Expression*-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHepatitis B, Chronic/complications-
dc.subject.MESHHepatitis B, Chronic/pathology-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/genetics*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHNeoplasm Recurrence, Local/genetics*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/virology-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPrognosis-
dc.titleGene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun GooWoo-
dc.contributor.googleauthorEun Sung Park-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorJu Han Kim-
dc.contributor.googleauthorJu-Seog Lee-
dc.contributor.googleauthorBumJoon Park-
dc.contributor.googleauthorWon Kim-
dc.contributor.googleauthorSu Cheol Park-
dc.contributor.googleauthorYoungJin Chung-
dc.contributor.googleauthorByeong Gwan Kim-
dc.contributor.googleauthorJung-HwanYoon-
dc.contributor.googleauthorHyo-Suk Lee-
dc.contributor.googleauthorChungYong Kim-
dc.contributor.googleauthorNam-JoonYi-
dc.contributor.googleauthorKyung-Suk Suh-
dc.contributor.googleauthorKuhn Uk Lee-
dc.contributor.googleauthorIn-Sun Chu-
dc.contributor.googleauthorTania Roskams-
dc.contributor.googleauthorSnorri S.Thorgeirsson-
dc.contributor.googleauthorYoonJun Kim-
dc.identifier.doi10.1158/1078-0432.CCR-07-1473-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01609-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ00564-
dc.identifier.pmid18381945-
dc.subject.keywordBiomarkers, Tumor/genetics*-
dc.subject.keywordCarcinoma, Hepatocellular/genetics*-
dc.subject.keywordCarcinoma, Hepatocellular/pathology-
dc.subject.keywordCarcinoma, Hepatocellular/virology-
dc.subject.keywordGene Expression*-
dc.subject.keywordGene Expression Profiling-
dc.subject.keywordHepatitis B virus-
dc.subject.keywordHepatitis B, Chronic/complications-
dc.subject.keywordHepatitis B, Chronic/pathology-
dc.subject.keywordHumans-
dc.subject.keywordKaplan-Meier Estimate-
dc.subject.keywordLiver Neoplasms/genetics*-
dc.subject.keywordLiver Neoplasms/pathology-
dc.subject.keywordLiver Neoplasms/virology-
dc.subject.keywordNeoplasm Recurrence, Local/genetics*-
dc.subject.keywordNeoplasm Recurrence, Local/pathology-
dc.subject.keywordNeoplasm Recurrence, Local/virology-
dc.subject.keywordOligonucleotide Array Sequence Analysis-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNamePark, Eun Sung-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.affiliatedAuthorPark, Eun Sung-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.rights.accessRightsfree-
dc.citation.volume14-
dc.citation.number7-
dc.citation.startPage2056-
dc.citation.endPage2064-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.14(7) : 2056-2064, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소) > 1. Journal Papers

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