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Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia

Authors
 Jaewoo Song  ;  Kyung A Lee  ;  Tae Sung Park  ;  Rojin Park  ;  Jong Rak Choi 
Citation
 ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol.38(4) : 368-375, 2008 
Journal Title
ANNALS OF CLINICAL AND LABORATORY SCIENCE
ISSN
 0091-7370 
Issue Date
2008
MeSH
ADAM Proteins/metabolism* ; ADAMTS13 Protein ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antithrombins/metabolism ; Blood Platelets/metabolism* ; Child ; Child, Preschool ; Collagen/metabolism ; Disseminated Intravascular Coagulation/enzymology* ; Disseminated Intravascular Coagulation/pathology ; Female ; Fibrinogen/metabolism ; Humans ; Infant ; Male ; Middle Aged ; Prognosis ; Thrombin/metabolism ; Thrombocytopenia/enzymology* ; Thrombocytopenia/pathology ; Young Adult ; von Willebrand Factor/metabolism
Keywords
platelet dynamics ; thrombocytopenia ; ADAMTS13 ; thrombin-antithrombin complex
Abstract
Von Willebrand factor (VWF) cleaving metalloprotease, ADAMTS13, known for its causative relation to thrombotic thrombocytopenic purpura (TTP), also decreases to variable degree in other clinical conditions associated with thrombocytopenia, indicating a possible contribution of moderate deficiency of ADAMTS13 to platelet dynamics. We measured ADAMTS13 activity along with VWF activity, collagen binding activity (VWF:CB), and thrombin/antithrombin complex (TAT) in plasma drawn from patients with consumptive coagulopathy, in whom the platelet count was closely followed. ADAMTS13 activity was significantly but variably decreased in the patients, and VWF activity and VWF:CB were markedly increased as expected. The platelet count itself was not correlated with ADAMTS13 activity, VWF activity, or VWF:CB. However, the rate of decline of log-scaled platelet count (DeltaLnPLT/day) correlated well with ADAMTS13 activity and VWF:CB. ADADMTS13 activity showed inverse correlation with VWF:CB. Moreover, the correlation between ADAMTS13 and DeltaLnPLT/day was preserved even after VWF:CB was controlled. Multiple regression analysis showed that ADAMTS13 activity was the sole factor explaining DeltaLnPLT/day among ADAMTS13, VWF:CB, TAT, prothrombin time, d-dimer, and fibrinogen. TAT level and d-dimer as indicators of systemic fibrinolytic activity did not correlate with ADAMTS13 activity. In conclusion, we found that the decrease of ADADMTS13 activity in consumptive coagulopathy has stronger relationship to platelet dynamics than has generally been recognized.
Full Text
http://www.annclinlabsci.org/content/38/4/368.long
DOI
18988930
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106653
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