Cited 4 times in
Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신동민 | - |
dc.contributor.author | 이승일 | - |
dc.contributor.author | 조해 | - |
dc.contributor.author | 최종훈 | - |
dc.contributor.author | 홍정희 | - |
dc.date.accessioned | 2015-05-19T16:37:11Z | - |
dc.date.available | 2015-05-19T16:37:11Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106637 | - |
dc.description.abstract | PURPOSE: The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), encoded by ATP2A2, is an essential component for G-protein coupled receptor (GPCR)-dependent Ca2+ signaling. However, whether the changes in Ca2+ signaling and Ca2+ signaling proteins in parotid acinar cells are affected by a partial loss of SERCA2 are not known. MATERIALS AND METHODS: In SERCA2+/- mouse parotid gland acinar cells, Ca2+ signaling, expression levels of Ca2+ signaling proteins, and amylase secretion were investigated. RESULTS: SERCA2+/- mice showed decreased SERCA2 expression and an upregulation of the plasma membrane Ca2+ ATPase. A partial loss of SERCA2 changed the expression level of 1, 4, 5-tris-inositolphosphate receptors (IP3Rs), but the localization and activities of IP3Rs were not altered. In SERCA2+/- mice, muscarinic stimulation resulted in greater amylase release, and the expression of synaptotagmin was increased compared to wild type mice. CONCLUSION: These results suggest that a partial loss of SERCA2 affects the expression and activity of Ca2+ signaling proteins in the parotid gland acini, however, overall Ca2+ signaling is unchanged. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 311~321 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amylases/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Calcium Signaling/drug effects | - |
dc.subject.MESH | Calcium Signaling/genetics | - |
dc.subject.MESH | Calcium Signaling/physiology* | - |
dc.subject.MESH | Carbachol/pharmacology | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Inositol 1,4,5-Trisphosphate Receptors/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Parotid Gland/metabolism* | - |
dc.subject.MESH | Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics | - |
dc.subject.MESH | Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism* | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Signal Transduction/genetics | - |
dc.subject.MESH | Signal Transduction/physiology | - |
dc.title | Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Oral Science Research Center (구강과학연구소) | - |
dc.contributor.googleauthor | Jong-Hoon Choi | - |
dc.contributor.googleauthor | Hae Jo | - |
dc.contributor.googleauthor | Jeong Hee Hong | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.identifier.doi | 10.3349/ymj.2008.49.2.311 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02091 | - |
dc.contributor.localId | A02924 | - |
dc.contributor.localId | A03924 | - |
dc.contributor.localId | A04188 | - |
dc.contributor.localId | A04434 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 18452270 | - |
dc.subject.keyword | sarco/endoplasmic reticulum Ca2+-ATPase | - |
dc.subject.keyword | Ca2+ signaling proteins | - |
dc.subject.keyword | parotid gland acinar cells | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.alternativeName | Jo, Hae | - |
dc.contributor.alternativeName | Choi, Jong Hoon | - |
dc.contributor.alternativeName | Hong, Jeong Hee | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Lee, Syng Ill | - |
dc.contributor.affiliatedAuthor | Jo, Hae | - |
dc.contributor.affiliatedAuthor | Choi, Jong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 321 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.49(2) : 311-321, 2008 | - |
dc.identifier.rimsid | 46624 | - |
dc.type.rims | ART | - |
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