Cited 13 times in
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경환 | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 조경주 | - |
dc.date.accessioned | 2015-05-19T16:36:54Z | - |
dc.date.available | 2015-05-19T16:36:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106628 | - |
dc.description.abstract | The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces age-dependent oxidative stress and selective striatal damage, which may simulate Huntington's disease starting in middle age. Recent reports showed that apoptosis signal-regulating kinase 1 (Ask1) activated by oxidative stress triggers a cell death signaling pathway. 3-NP was injected to the striatum in C57BL/6J mice. We have confirmed that striatal lesion volume and DNA fragmentation were age-dependent after 3-NP treatment. In the non-injured striatum of the middle-aged group, the protein levels of Ask1 and its active form, phosphorylated Ask1 (pAsk1), were significantly higher than in the young group. Ask1 increased more in the 3-NP injured striatum of the middle-aged group than in the non-injured striatum, and subsequently the activity of pAsk1 was significantly higher than in the young group. However, middle-aged SOD1Tg mice showed significant reductions of Ask1 and pAsk1 in the injured and the non-injured striatum compared to the middle-aged group. In particular, apoptosis signal transduction and cell death were significantly inhibited by the reduction of Ask1 expression using siRNA. Present results suggest that age-related upregulation of Ask1 and oxidative stress may mediate age-dependent striatal vulnerability to 3-NP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 142~146 | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aging/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Convulsants/pharmacology* | - |
dc.subject.MESH | Corpus Striatum/drug effects* | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | In Situ Nick-End Labeling/methods | - |
dc.subject.MESH | Indoles | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 5/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Nitro Compounds/pharmacology* | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Propionates/pharmacology* | - |
dc.subject.MESH | RNA, Small Interfering/pharmacology | - |
dc.subject.MESH | Superoxide Dismutase/genetics | - |
dc.subject.MESH | Superoxide Dismutase-1 | - |
dc.title | Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Yangki Minn | - |
dc.contributor.googleauthor | Kyoung-Joo Cho | - |
dc.contributor.googleauthor | Hyun-Woo Kim | - |
dc.contributor.googleauthor | Hyun-Jeong Kim | - |
dc.contributor.googleauthor | Seung-Han Suk | - |
dc.contributor.googleauthor | Byung I. Lee | - |
dc.contributor.googleauthor | Gyung W. Kim | - |
dc.identifier.doi | 10.1016/j.neulet.2007.10.042 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00310 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A03804 | - |
dc.contributor.localId | A01125 | - |
dc.contributor.localId | A01130 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 18063477 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394007011470 | - |
dc.subject.keyword | 3-Nitropropionic acid | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Ask1 | - |
dc.subject.keyword | Aging | - |
dc.subject.keyword | Vulnerability | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jeong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 430 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 146 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.430(2) : 142-146, 2008 | - |
dc.identifier.rimsid | 46155 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.