Cited 26 times in
Effect of propofol on calcium homeostasis in hypoxia-reoxygenated neonatal rat cardiomyocytes
DC Field | Value | Language |
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dc.contributor.author | 김현수 | - |
dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 장우철 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-05-19T16:34:46Z | - |
dc.date.available | 2015-05-19T16:34:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106564 | - |
dc.description.abstract | Intracellular Ca2+ overload induced by hypoxia-reoxygenation alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Even though propofol is known as a radical scavenger with Ca2+ channel blocking properties, little is known about cardioprotective effect associated with Ca2+ homeostasis in cardiomyocytes. In the present study, we showed that propofol protects cardiomyocytes against hypoxia-reoxygenation injury. In propofol-treated cardiomyocytes, we observed a decrease in the expression of pro-apoptotic protein Bax, cytochrome c, caspase-3 activation and intracellular Ca2+ content. We also found that propofol treatment enhanced expression of anti-apoptotic protein Bcl-2 and activation of ERK concerned with survival. Propofol attenuated alterations of genes involving Ca2+-regulatory mechanism and significantly modulated abnormal changes of SERCA2a genes in hypoxia-reoxygenated neonatal cardiomyocytes. These results suggest that propofol modulates the expression of genes involved in Ca2+ homeostasis, thereby producing cardioprotective effects through a reduction in apoptotic cell death. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 139~145 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Intravenous/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Calcium/metabolism* | - |
dc.subject.MESH | Calcium-Binding Proteins/biosynthesis | - |
dc.subject.MESH | Calcium-Binding Proteins/genetics | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Cell Hypoxia/drug effects* | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Gene Expression/drug effects | - |
dc.subject.MESH | Homeostasis/drug effects* | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Confocal | - |
dc.subject.MESH | Myocytes, Cardiac/drug effects* | - |
dc.subject.MESH | Nerve Tissue Proteins/biosynthesis | - |
dc.subject.MESH | Nerve Tissue Proteins/genetics | - |
dc.subject.MESH | Propofol/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.title | Effect of propofol on calcium homeostasis in hypoxia-reoxygenated neonatal rat cardiomyocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyun-Soo Kim | - |
dc.contributor.googleauthor | Woo-Chul Chang | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | In-Geol Choi | - |
dc.contributor.googleauthor | Wyun-Kon Park | - |
dc.identifier.doi | 10.1016/j.ejphar.2008.07.027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A03452 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A01113 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 18674530 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0014299908007425 | - |
dc.subject.keyword | Propofol | - |
dc.subject.keyword | Ca2+homeostasis | - |
dc.subject.keyword | Hypoxia-reoxygenation | - |
dc.subject.keyword | Cardiomyocytes | - |
dc.contributor.alternativeName | Kim, Hyun Soo | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Chang, Woo Chul | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Chang, Woo Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 594 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 139 | - |
dc.citation.endPage | 145 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.594(1-3) : 139-145, 2008 | - |
dc.identifier.rimsid | 44951 | - |
dc.type.rims | ART | - |
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