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Nomograms for prediction of disease recurrence in patients with primary Ta, T1 transitional cell carcinoma of the bladder

Authors
 Sung Joon Hong  ;  Kang Su Cho  ;  Mooyoung Han  ;  Hyun Yul Rhew  ;  Choung-Soo Kim  ;  Soo Bang Ryu  ;  Chong Koo Sul  ;  Moon Kee Chung  ;  Tong Choon Park  ;  Hyung Jin Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.23(3) : 428-433, 2008 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2008
MeSH
Aged ; Carcinoma in Situ/diagnosis ; Carcinoma in Situ/epidemiology ; Carcinoma, Transitional Cell/diagnosis* ; Carcinoma, Transitional Cell/epidemiology* ; Disease-Free Survival ; Female ; Humans ; Male ; Multivariate Analysis ; Nomograms* ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Recurrence ; Regression Analysis ; Reproducibility of Results ; Urinary Bladder Neoplasms/diagnosis* ; Urinary Bladder Neoplasms/epidemiology*
Keywords
Carcinoma ; Transitional Cell ; Urinary Bladder ; Recurrence ; Nomograms
Abstract
We developed nomograms to predict disease recurrence in patients with Ta, T1 transitional cell carcinoma of the bladder. Thirty-eight training hospitals participated in this retrospective multicenter study. Between 1998 and 2002, a total of 1,587 patients with newly diagnosed non-muscle invasive bladder cancer were enrolled in this study. Patients with prior histories of bladder cancer, non-transitional cell carcinoma, or a follow-up duration of less than 12 months were excluded. With univariate and multivariate logistic regression analyses, we constructed nomograms to predict disease recurrence, and internal validation was performed using statistical techniques. Three-year and five-year recurrence-free rates were 64.3% and 55.3%, respectively. Multivariate analysis revealed that age (hazard ratio [HR]=1.437, p<0.001), tumor size (HR=1.328, p=0.001), multiplicity (HR=1.505, p<0.001), tumor grade (HR=1.347, p=0.007), concomitant carcinoma in situ (HR=1.611, p=0.007), and intravesical therapy (HR=0.681, p<0.001) were independent predictors for disease recurrence. Based on these prognostic factors, nomograms for the prediction of disease recurrence were developed. These nomograms can be used to predict the probability of disease recurrence in patients with newly diagnosed Ta, T1 transitional cell carcinoma of the bladder. They may be useful for patient counseling, clinical trial design, and patient follow-up planning
Files in This Item:
T200800375.pdf Download
DOI
10.3346/jkms.2008.23.3.428
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Han, Moo Young(한무영)
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106536
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