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The association between adiponectin and diabetes in the Korean population

Authors
 Soo Jin Yoon  ;  Hong Soo Lee  ;  Sang Wha Lee  ;  Ji Eun Yun  ;  Sang Yon Kim  ;  Eo Rin Cho  ;  Sun Ju Lee  ;  Eun Jung Jee  ;  Hee Yeon Lee  ;  Jungyong Park  ;  Hyon-Suk Kim  ;  Sun Ha Jee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.57(6) : 853-857, 2008 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2008
MeSH
Adiponectin/blood* ; Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Diabetes Mellitus/blood* ; Diabetes Mellitus/etiology ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Sex Characteristics ; Triglycerides/blood
Keywords
Adiponectin/blood* ; Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Diabetes Mellitus/blood* ; Diabetes Mellitus/etiology ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Sex Characteristics ; Triglycerides/blood
Abstract
As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049508000644
DOI
10.1016/j.metabol.2008.01.031
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Yun, Soo Jin(윤수진)
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106468
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