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Beta-catenin gene alterations in a variety of so-called calcifying odontogenic cysts

Authors
 SANG-GUN AHN  ;  SOO-A KIM  ;  SU-GWAN KIM  ;  SANG-HO LEE  ;  JIN KIM  ;  JUNG-HOON YOON 
Citation
 APMIS, Vol.116(3) : 206-211, 2008 
Journal Title
 APMIS 
ISSN
 0903-4641 
Issue Date
2008
MeSH
Adult ; Child ; Female ; Humans ; Immunohistochemistry ; Jaw Neoplasms/metabolism* ; Male ; Middle Aged ; Odontogenic Cyst, Calcifying/metabolism* ; Signal Transduction ; Wnt Proteins/physiology ; beta Catenin/analysis ; beta Catenin/genetics*
Keywords
Calcifying odontogenic cyst ; b-catenin ; Wnt
Abstract
Calcifying odontogenic cysts (COCs) evidence a variety of histopathological features, in addition to biological behaviors. Several systems have been proposed for the classification of COCs. However, the molecular changes underlying their development remain largely unknown. In an effort to elucidate the participation of beta-catenin gene mutation in COC development, we evaluated the genetic alterations and expression of beta-catenin in different COC subtypes with archival paraffin blocks. beta-catenin gene mutations were detected in all subtypes. Immunohistochemically, all cases of COCs evidenced cytoplasmic and nuclear beta-catenin expression. Beta-catenin gene mutations and beta-catenin overexpression have been identified as characteristics of COCs. Therefore, the constitutive activation of Tcf/Lef-dependent transcription appears to be intimately involved in their development. These findings indicate that aberrations of the Wnt signaling pathway may perform a crucial role in the development and differentiation status of the odontogenic epithelium in COCs via the deregulation of cell proliferation.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2008.00893.x/abstract
DOI
10.1111/j.1600-0463.2008.00893.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106443
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