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Quantification of thalamocortical tracts in schizophrenia on probabilistic maps

Authors
 Dae-Jin Kim  ;  Jae-Jin Kim  ;  JinYoung Park  ;  SooYeol Lee  ;  Joongil Kim  ;  InYoung Kim  ;  Sun I. Kim  ;  Hae-Jeong Park 
Citation
 NEUROREPORT, Vol.19(4) : 399-403, 2008 
Journal Title
NEUROREPORT
ISSN
 0959-4965 
Issue Date
2008
MeSH
Adult ; Anisotropy ; Atrophy/etiology ; Atrophy/pathology* ; Atrophy/physiopathology ; Brain Mapping ; Cerebral Cortex/pathology* ; Cerebral Cortex/physiopathology ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Extracellular Fluid/metabolism ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Models, Statistical* ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Nerve Fibers, Myelinated/pathology* ; Neural Pathways/pathology ; Neural Pathways/physiopathology ; Predictive Value of Tests ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology ; Schizophrenia/pathology* ; Schizophrenia/physiopathology ; Thalamus/pathology* ; Thalamus/physiopathology
Keywords
di¡usion tensor imaging ; longitudinal apparent di¡usion coe⁄cient ; schizophrenia ; thalamocortical connection ; transversal apparent di¡usioncoe⁄cient
Abstract
Diffusion properties of the thalamocortical pathways were compared between 30 schizophrenic patients and 22 healthy age-matched and sex-matched volunteers. T1-weighted and diffusion tensor images were used for cortical parcellation and probabilistic tractography to generate population-based thalamocortical pathway maps. The weighted fractional anisotropy and the longitudinal and transversal diffusivity of each pathway were calculated for individual participants. Patients with schizophrenia demonstrated decreased anisotropy and increased longitudinal and transversal diffusivity within the pathways from the mediodorsal nucleus and the pulvinar to the orbitofrontal and parietal-occipital-temporal lobes. Anisotropy decreases and diffusivity increases were correlated with positive and negative syndrome scale scores. Alterations in global diffusion properties within the thalamocortical pathways imply the disruption of brain circuitry in schizophrenic patients.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200803050-00002&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e3282f56634
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106430
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