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젊은 남자 환자에서 작용 발현 시간에 천장 효과가 나타나는 Rocuronium의 용량

Other Titles
 Rocuronium Dosage Producing the Ceiling Effect on Onset Time in Young Male Patients 
Authors
 김태완  ;  한동우  ;  강연승  ;  신양식 
Citation
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.54(4) : 378-383, 2008 
Journal Title
KOREAN JOURNAL OF ANESTHESIOLOGY(대한마취과학회지)
ISSN
 2005-6419 
Issue Date
2008
Keywords
ceiling effect ; onset time ; recovery time ; rocuronium
Abstract
Background: Rocuronium is considered a good candidate for rapid-sequence induction of anesthesia. Increased dose of rocuronium shortens the onset time but prolongs the duration of action. However, the ceiling effect of onset time appears when larger doses are used. Clinical trials have not shown the exact dose of ceiling effect. We performed this study to find dose producing the ceiling effect of onset time.
Methods: One hundred forty young male adults were randomized to oneof seven doses of rocuronium: 0.6, 0.7, 0.8, 0.9, 1.0, 1.1 or 1.2 mg/kg. Anesthesia was induced with IV thiopental sodium and maintained with sevoflurane after tracheal intubation. Neuromuscular block was monitored with acceleromyography using single twitch. The onset time, the recovery of single twitch to 10% and also the changes in hemodynamics were checked.
Results: A dose of up to 1.0 mg/kg shortens the onset time but no further decrement was seen with doses larger than 1.0 mg/kg. The recovery time was prolonged as doses were increased but there were no differences in the hemodynamics.
Conclusions: This study showed that in young male adults under IV induction with thiopental sodium, the ceiling effect of onset time appeared with rocuronium doses in excess of 1.0 mg/kg
Files in This Item:
T200800224.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yang Sik(신양식)
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106365
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