Cited 2 times in
Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 김인숙 | - |
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2015-05-19T16:23:28Z | - |
dc.date.available | 2015-05-19T16:23:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106219 | - |
dc.description.abstract | Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus, resulting in an increase in its DNA-binding activity to the EPO enhancer. Zinc inhibited hypoxia-induced increases in HIF-1 DNA-binding activity and the HIF-1-dependent mRNA expression of EPO. Zinc did not affect hypoxic stabilization of HIF-1alpha. Nuclear migration of HIF-1alpha upon hypoxia was reduced by zinc. Complete blockade of hypoxia-induced assembly of HIF-1alpha-HIF-1beta complex was observed after treatment of zinc. These findings suggest that zinc hampers hypoxia-stimulated HIF-1 activation in astrocytes by inhibiting nuclear HIF-1alpha translocation and subsequently disrupting HIF-1 heterodimerization | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1063~1066 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology | - |
dc.subject.MESH | Astrocytoma/pathology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Tumor | - |
dc.subject.MESH | Cell Nucleus/metabolism | - |
dc.subject.MESH | Dose-Response Relationship | - |
dc.subject.MESH | Drug | - |
dc.subject.MESH | Drug Interactions | - |
dc.subject.MESH | Electrophoretic Mobility Shift Assay/methods | - |
dc.subject.MESH | Erythropoietin/genetics | - |
dc.subject.MESH | Erythropoietin/metabolism | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Neoplastic/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia/metabolism* | - |
dc.subject.MESH | Hypoxia-Inducible Factor 1 | - |
dc.subject.MESH | alpha Subunit/metabolism* | - |
dc.subject.MESH | Proline/analogs & derivatives | - |
dc.subject.MESH | Proline/pharmacology | - |
dc.subject.MESH | Protein Transport/drug effects | - |
dc.subject.MESH | Thiocarbamates/pharmacology | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Zinc Sulfate/pharmacokinetics* | - |
dc.subject.MESH | Zinc Sulfate/pharmacology | - |
dc.title | Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Insook Kim | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Gi Ho Seo | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Jinu Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Young Soo Ahn | - |
dc.identifier.doi | 10.1097/WNR.0b013e328304d9ac | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00842 | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 18580580 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200807020-00013&LSLINK=80&D=ovft | - |
dc.subject.keyword | astrocytes | - |
dc.subject.keyword | erythropoietin | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | hypoxia-inducible factor-1 | - |
dc.subject.keyword | zinc | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, In Sook | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Ahn, Young Soo | - |
dc.contributor.affiliatedAuthor | Kim, In Sook | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Ahn, Young Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1063 | - |
dc.citation.endPage | 1066 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.19(10) : 1063-1066, 2008 | - |
dc.identifier.rimsid | 56285 | - |
dc.type.rims | ART | - |
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