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SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas.

DC Field Value Language
dc.contributor.author김경환-
dc.date.accessioned2015-05-19T16:22:03Z-
dc.date.available2015-05-19T16:22:03Z-
dc.date.issued2008-
dc.identifier.issn1357-2725-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/106176-
dc.description.abstractInduction of proinflammatory cytokines IL-6 and TGF-beta1 are the hallmark of human pancreatitis. Cerulein pancreatitis is similar to human edematous pancreatitis involving dysregulation of digestive enzyme production, cytoplasmic vacuolization, and increased cytokine production. We previously showed that cerulein induced IL-1beta expression through the Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway in pancreatic acinar cells. Suppressor of cytokine signaling (SOCS) is a negative feedback regulator of JAK/STAT signaling. In this study, we demonstrate that SOCS 3 is induced by cerulein in pancreatic acinar AR42J cells and in the rat pancreas. In both AR42J cells and rat pancreas, cerulein induced expression of IL-6 and TGF-beta1, which is enhanced by transfection or injection of SOCS 3 antisense oligonucleotide (AS ODN). Pre-treating cerulein-stimulated AR42J cells or rats with the peroxisome proliferator activated receptor-gamma (PPAR-gamma) ligands, 15d-PGJ2 and troglitazone, induced SOCS 3 expression and inhibited JAK2/STAT3 activation. This treatment regimen also inhibited IL-6 and TGF-beta1 induction, vacuolization, and alpha-smooth muscle actin (alpha-SMA) expression. Thus, SOCS 3 expression is associated with a reduction in IL-6 and TGF-beta1 expression, edema formation, vacuolization, and alpha-SMA expression, possibly by direct regulation of JAK2/STAT3 signaling. 15d-PGJ2 and troglitazone are potentially useful pancreatitis therapies by suppressing the JAK2/STAT3 inflammatory signaling through SOCS 3 induction-
dc.description.statementOfResponsibilityopen-
dc.format.extent677~688-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCeruletide/pharmacology-
dc.subject.MESHChromans/pharmacology-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHInterleukin-6/genetics-
dc.subject.MESHInterleukin-6/metabolism*-
dc.subject.MESHJanus Kinase 2/metabolism-
dc.subject.MESHMale-
dc.subject.MESHPPAR gamma/metabolism*-
dc.subject.MESHPancreas/drug effects-
dc.subject.MESHPancreas/metabolism*-
dc.subject.MESHProstaglandin D2/analogs & derivatives-
dc.subject.MESHProstaglandin D2/pharmacology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSTAT3 Transcription Factor/metabolism-
dc.subject.MESHSignal Transduction/drug effects-
dc.subject.MESHSignal Transduction/physiology*-
dc.subject.MESHSuppressor of Cytokine Signaling 3 Protein-
dc.subject.MESHSuppressor of Cytokine Signaling Proteins/genetics-
dc.subject.MESHSuppressor of Cytokine Signaling Proteins/metabolism*-
dc.subject.MESHThiazolidinediones/pharmacology-
dc.subject.MESHTransforming Growth Factor beta1/genetics-
dc.subject.MESHTransforming Growth Factor beta1/metabolism*-
dc.titleSOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJi Hoon Yu-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorHyeyoung Kim-
dc.identifier.doi10.1016/j.biocel.2007.10.007-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ01089-
dc.identifier.eissn1878-5875-
dc.identifier.pmid18035585-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1357272507003226-
dc.subject.keywordSOCS 3-
dc.subject.keywordPPAR-γ-
dc.subject.keywordJAK2/STAT3-
dc.subject.keywordPancreas-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.rights.accessRightsnot free-
dc.citation.volume40-
dc.citation.number4-
dc.citation.startPage677-
dc.citation.endPage688-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Vol.40(4) : 677-688, 2008-
dc.identifier.rimsid54774-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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