0 298

Cited 41 times in

Tissue Doppler index, E/E', and ischemic stroke in patients with atrial fibrillation and preserved left ventricular ejection fraction

Authors
 Sang-Hak Lee  ;  Seonghoon Choi  ;  Wook-Jin Chung  ;  Young-Sup Byun  ;  Sung-Kee Ryu  ;  Wook-Bum Pyun  ;  Se-Joong Rim 
Citation
 JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.271(1-2) : 148-152, 2008 
Journal Title
 JOURNAL OF THE NEUROLOGICAL SCIENCES 
ISSN
 0022-510X 
Issue Date
2008
MeSH
Aged ; Atrial Fibrillation/complications* ; Atrial Fibrillation/diagnostic imaging ; Blood Flow Velocity ; Cardiac Volume/physiology* ; Chi-Square Distribution ; Echocardiography, Doppler* ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Odds Ratio ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Stroke/complications* ; Stroke/diagnostic imaging ; Ventricular Dysfunction, Left/diagnostic imaging* ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left*
Keywords
Atrial fibrillation ; Cerebrovascular accident ; Doppler echocardiography ; Echocardiography ; Diastole ; Ventricular function ; Heart failure
Abstract
BACKGROUND: Although several risk factors for stroke have been reported in patients with atrial fibrillation (AF), the relation of LV diastolic dysfunction to stroke is still uncertain in these patients. We evaluated the relationship between tissue Doppler-derived index, E/E', as well as other clinical and echocardiographic parameters and ischemic stroke by this cross-sectional study. METHODS: Three hundred thirty patients with persistent AF who had preserved LV ejection fraction were included from 6 centers. Clinical data were obtained and standard transthoracic echocardiography was performed. Patients without a history of ischemic stroke (n=280) were compared with patients with this complication (n=50). Potential determinants of ischemic stroke were identified by logistic regression analyses. RESULTS: In univariate analyses, age, history of hypertension, diabetes mellitus, hyperlipidemia and symptomatic heart failure, plasma brain natriuretic peptide (BNP) level, early mitral inflow velocity (E), diastolic mitral annular velocity (E'), and E/E' ratio were significantly correlated to ischemic stroke. Multivariate regression analyses identified two significant variables that were independently associated with ischemic stroke: hypertension (odds ratio=6.03, p=0.008), and E/E' (odds ratio=1.21, p=0.002). CONCLUSIONS: These findings may have clinical implications that LV diastolic dysfunction, reflected by E/E', is a significant determinant of ischemic stroke in AF. A larger prospective data is needed to confirm the value of E/E' in risk stratification for ischemic stroke in this population
Full Text
http://www.sciencedirect.com/science/article/pii/S0022510X08001664
DOI
10.1016/j.jns.2008.04.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Byun, Young Sup(변영섭)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Wook Jin(정욱진)
Choi, Seong Hoon(최성훈)
Pyun, Wook Bum(편욱범)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/106135
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links