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Usefulness of brachial-ankle pulse wave velocity as a predictive marker of multiple coronary artery occlusive disease in Korean type 2 diabetes patients.

 Hai Jin Kim  ;  Ji Sun Nam  ;  Jong Suk Park  ;  Minho Cho  ;  Chul Sik Kim  ;  Chul Woo Ahn  ;  Hyuck Moon Kwon  ;  Bum Kee Hong  ;  Young Won Yoon  ;  Bong Soo Cha  ;  Kyung Rae Kim  ;  Hyun Chul Lee 
 Diabetes Research and Clinical Practice, Vol.85(1) : 30-34, 2009 
Journal Title
 Diabetes Research and Clinical Practice 
Issue Date
Aged ; Ankle/blood supply* ; Ankle Brachial Index/methods* ; Arterial Occlusive Diseases/physiopathology* ; Blood Pressure ; C-Reactive Protein/metabolism ; Coronary Disease/physiopathology* ; Diabetes Mellitus, Type 2/complications* ; Diabetic Angiopathies/physiopathology* ; Female ; Humans ; Korea ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Pulse ; Sensitivity and Specificity
Type 2 diabetes ; Multivessel coronary artery occlusive disease ; Brachial-ankle pulse wave velocity
Multiple coronary artery occlusive disease (multiple CAOD) is the most fatal and frequently observed coronary artery disease in type 2 diabetes patients, but no simple, non-invasive screening tool is available yet. The aim of this study is to evaluate the arterial stiffness in type 2 diabetes patients using brachial-ankle pulse wave velocity (baPWV), to demonstrate the correlation between arterial stiffness and multiple CAOD, and to suggest the cutoff point of baPWV for predicting multiple CAOD in Korean type 2 diabetes patients. One hundred and eighty-one diabetes and 262 non-diabetes patients were enrolled in the study. Routine anthropometric and serologic data were collected. baPWV was measured the day before coronary angiography, and the severity of CAOD was assessed with Gensini score after angiography. baPWV and Gensini score were significantly increased in diabetes patients and Gensini score had a positive correlation with baPWV. Subjects in the highest tertile of baPWV showed odds ratio of 3.06 for multiple CAOD compared to the lowest tertile. In ROC curve, baPWV at 1635 cm/s showed 73% sensitivity and 75% specificity with AUC 0.76 in diabetes patients in detecting multiple CAOD. Therefore, baPWV may be utilized a screening tool for predicting multiple CAOD, especially in type 2 diabetes patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Kyung Rae(김경래)
Kim, Chul Sik(김철식)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Lee, Hyun Chul(이현철)
Cho, Min Ho(조민호)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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