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Lamotrigine을 복용한 간질 여성의 임신 예후

Other Titles
 Pregnancy outcomes in women with epilepsy using lamotrigine 
Authors
 Maria Lee  ;  Ka Hyun Nam  ;  Ja Young Kwon  ;  Yong Won Park  ;  Young Han Kim 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.52(12) : 1245-1251, 2009 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) 
ISSN
 2233-5188 
Issue Date
2009
Keywords
Epilepsy ; Antiepileptic drug ; Pregnancy outcomes ; Lamotrigine
Abstract
Objective: The purpose of this study was to investigate pregnancy outcomes in women with epilepsy using lamotrigine (LTG). Methods: We retrospectively reviewed the medical records of all patients who had been diagnosed as epilepsy and gave live singleton births in Yonsei University Health System, Seoul, Korea, between February 1996 and December 2007. Nine patients who were not taking antiepileptic drugs (AEDs) were excluded from this study. We subdivided the enrolled patients into 2 groups; patients exposed to LTG and others exposed to other AEDs. Congenital malformation, spontaneous abortion, small for gestational age, termination of pregnancy, intrauterine fetal death, preterm delivery, and adverse maternal outcomes were documented to evaluate the pregnancy outcomes. The statistical significance was defined as P<0.05. Results: 129 cases were found in all medical records. The overall risk of congenital malformations in the AED group was 6.2% (n=8), which included 4 cases to carbamazepine (CBZ) monotherapy, 1 to valproate (VPA) monotherapy, and 3 to VPA+CBZ polytherapy. Congenital malformations were significantly increased in the non-LTG groups than in the LTG group (8.7% vs. 0%, P=0.047), especially in non-LTG polytherapy group (20.0% vs. 0%, P=0.049). The rates of spontaneous abortion, small for gestational age, termination of pregnancy, intrauterine fetal death, preterm delivery, and adverse maternal outcomes were no significant differences between the two groups. Conclusion: This study demonstrates that administration of LTG in pregnant women with epilepsy could be more effective in decreasing teratogenicity than administration of other AEDs in polytherapy
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Nam, Ka Hyun(남가현)
Park, Yong Won(박용원)
Lee, Maria(이마리아)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105989
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