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Comparison of monthly ibandronate versus weekly risedronate in preference, convenience, and bone turnover markers in Korean postmenopausal osteoporotic women.

Authors
 Yoon-Sok Chung  ;  Sung-Kil Lim  ;  Ho-Yeon Chung  ;  In-Kyu Lee  ;  Il-Hyung Park  ;  Ghi-Su Kim  ;  Yong-Ki Min  ;  Moo-Il Kang  ;  Dong-Jin Chung  ;  Yong-Ki Kim  ;  Woong Hwan Choi  ;  Min Ho Shong  ;  Ji-Hyun Park  ;  Dong-Won Byun  ;  Hyun-Koo Yoon  ;  Chan Soo Shin  ;  Yil-Seob Lee  ;  Nam-Hee Kwon 
Citation
 CALCIFIED TISSUE INTERNATIONAL, Vol.85(5) : 389-397, 2009 
Journal Title
 CALCIFIED TISSUE INTERNATIONAL 
ISSN
 0171-967X 
Issue Date
2009
MeSH
Aged ; Bone Density Conservation Agents/administration & dosage* ; Bone Density Conservation Agents/therapeutic use ; Bone and Bones/metabolism ; Collagen Type I/metabolism ; Cross-Over Studies ; Diphosphonates/administration & dosage* ; Diphosphonates/therapeutic use ; Drug Administration Schedule ; Etidronic Acid/administration & dosage ; Etidronic Acid/analogs & derivatives* ; Etidronic Acid/therapeutic use ; Female ; Humans ; Korea ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy* ; Osteoporosis, Postmenopausal/epidemiology ; Osteoporosis, Postmenopausal/metabolism ; Patient Preference ; Peptides/metabolism ; Prospective Studies ; Risedronate Sodium
Keywords
Ibandronate ; Risedronate ; Preference ; Convenience ; Korean
Abstract
Patient preferences, convenience, and bone turnover markers were evaluated for the monthly ibandronate over the weekly risedronate regimen in Korean postmenopausal osteoporotic women. This was a 6-month, prospective, randomized, open-label, multicenter study with a two-period and two-sequence crossover treatment design. After a 30-day screening period, eligible participants with postmenopausal osteoporosis were randomized to receive either monthly oral ibandronate 150 mg for 3 months followed by weekly oral risedronate 35 mg for 12 weeks (sequence A) or the same regimen in reverse order (sequence B). Patient preference and convenience were evaluated by questionnaire. The changes in serum C-telopeptide after 3 months of treatment were analyzed. A total of 365 patients were enrolled in this study (sequence A 182, sequence B 183). Of patients expressing a preference (83.4%), 74.8% preferred the monthly ibandronate regimen over the weekly regimen (25.2%). More women stated that the monthly ibandronate regimen was more convenient (84.2%) than the weekly regimen (15.8%). There was no significant difference in the change in bone turnover marker between the two treatments. The two regimens were similarly tolerable. There were fewer adverse events in the monthly ibandronate group compared to the weekly risedronate group in terms of gastrointestinal side effects (nausea and abdominal distension). This study revealed a strong preference and convenience for monthly ibandronate over weekly risedronate in Korean postmenopausal osteoporotic women. There was no significant difference in change of bone turnover marker and safety profile between the two regimens.
Files in This Item:
T200905930.pdf Download
DOI
10.1007/s00223-009-9294-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105972
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