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Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing Raav2
DC Field | Value | Language |
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dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2015-04-24T17:39:41Z | - |
dc.date.available | 2015-04-24T17:39:41Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105825 | - |
dc.description.abstract | Recently, we demonstrated that the administration of GAD65-expressing rAAV2 to DRG attenuates peripheral neuropathy by inducing GABA release in the spinal cord. However, the direct injection to DRG is invasive and may therefore cause nerve injury and other side effects. To circumvent this surgical intervention, we explored the potential of a much simpler and less invasive route of sciatic nerve administration. Using a neuropathic pain model, we introduced rAAV2-GAD65 through sciatic nerve and examined its therapeutic potency in pain-related behavior tests. Both GFP and GAD65 expression indicated that effective transgene delivery to the DRG can be accomplished via sciatic nerve administration. Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled. The implication is that the sciatic nerve is a highly promising route for delivering rAAV2 to the DRG, and thus represents a much less invasive, clinically viable gene therapy option. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~78 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoviridae* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Ganglia, Spinal | - |
dc.subject.MESH | Gene Transfer Techniques | - |
dc.subject.MESH | Genetic Therapy/methods* | - |
dc.subject.MESH | Glutamate Decarboxylase/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neuralgia/etiology | - |
dc.subject.MESH | Neuralgia/therapy* | - |
dc.subject.MESH | Peripheral Nervous System Diseases/complications | - |
dc.subject.MESH | Peripheral Nervous System Diseases/therapy* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Sciatic Nerve* | - |
dc.title | Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing Raav2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jaehyung Kim | - |
dc.contributor.googleauthor | Sung Jin Kim | - |
dc.contributor.googleauthor | Heuiran Lee | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.07.120 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 19643087 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X0901479X | - |
dc.subject.keyword | Neuropathic pain | - |
dc.subject.keyword | Sciatic nerve | - |
dc.subject.keyword | rAAV2 | - |
dc.subject.keyword | GAD65 | - |
dc.subject.keyword | GABA | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.citation.volume | 388 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.388(1) : 73-78, 2009 | - |
dc.identifier.rimsid | 49869 | - |
dc.type.rims | ART | - |
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