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Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing Raav2

DC Field Value Language
dc.contributor.author장진우-
dc.date.accessioned2015-04-24T17:39:41Z-
dc.date.available2015-04-24T17:39:41Z-
dc.date.issued2009-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105825-
dc.description.abstractRecently, we demonstrated that the administration of GAD65-expressing rAAV2 to DRG attenuates peripheral neuropathy by inducing GABA release in the spinal cord. However, the direct injection to DRG is invasive and may therefore cause nerve injury and other side effects. To circumvent this surgical intervention, we explored the potential of a much simpler and less invasive route of sciatic nerve administration. Using a neuropathic pain model, we introduced rAAV2-GAD65 through sciatic nerve and examined its therapeutic potency in pain-related behavior tests. Both GFP and GAD65 expression indicated that effective transgene delivery to the DRG can be accomplished via sciatic nerve administration. Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled. The implication is that the sciatic nerve is a highly promising route for delivering rAAV2 to the DRG, and thus represents a much less invasive, clinically viable gene therapy option.-
dc.description.statementOfResponsibilityopen-
dc.format.extent73~78-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoviridae*-
dc.subject.MESHAnimals-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGanglia, Spinal-
dc.subject.MESHGene Transfer Techniques-
dc.subject.MESHGenetic Therapy/methods*-
dc.subject.MESHGlutamate Decarboxylase/genetics*-
dc.subject.MESHMale-
dc.subject.MESHNeuralgia/etiology-
dc.subject.MESHNeuralgia/therapy*-
dc.subject.MESHPeripheral Nervous System Diseases/complications-
dc.subject.MESHPeripheral Nervous System Diseases/therapy*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSciatic Nerve*-
dc.titleEffective neuropathic pain relief through sciatic nerve administration of GAD65-expressing Raav2-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorJaehyung Kim-
dc.contributor.googleauthorSung Jin Kim-
dc.contributor.googleauthorHeuiran Lee-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1016/j.bbrc.2009.07.120-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid19643087-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X0901479X-
dc.subject.keywordNeuropathic pain-
dc.subject.keywordSciatic nerve-
dc.subject.keywordrAAV2-
dc.subject.keywordGAD65-
dc.subject.keywordGABA-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.citation.volume388-
dc.citation.number1-
dc.citation.startPage73-
dc.citation.endPage78-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.388(1) : 73-78, 2009-
dc.identifier.rimsid49869-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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