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Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | 남주현 | - |
dc.date.accessioned | 2015-04-24T17:38:57Z | - |
dc.date.available | 2015-04-24T17:38:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105802 | - |
dc.description.abstract | Menthol, a naturally occurring compound from peppermint oil, binds and activates the TRPM8 Ca(2+)-permeable channel that exhibits abnormal expression patterns in prostate cancer, suggesting that TRPM8 links Ca(2+) transport pathways to tumor biology. We thus investigated the cellular responses of prostate cancer cells to menthol. Here we found that menthol increases [Ca(2+)](i) via Ca(2+) influx mechanism(s) independent of TRPM8 in PC-3 cells. We demonstrated that menthol induces cell death at supramillimolar concentrations in PC-3 cells and the cell death is not suppressed by low extracellular Ca(2+) condition which indicates that menthol-induced cell death is not associated with Ca(2+) influx pathways. In addition, we showed that menthol increases a phosphorylated form of c-jun N-terminal kinase (JNK) in PC-3 cells through TRPM8-independent mechanisms. Thus, our data indicate that there is an apparent lack of causality between TRPM8 activation and menthol-induced cell death and that menthol can regulate TRPM8-independent Ca(2+)-transport and cellular processes | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~38 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Calcium Channels/metabolism | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Death/physiology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ion Transport/drug effects | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Menthol/pharmacology* | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism | - |
dc.subject.MESH | Prostatic Neoplasms/drug therapy* | - |
dc.subject.MESH | Prostatic Neoplasms/genetics | - |
dc.subject.MESH | Prostatic Neoplasms/metabolism* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | TRPA1 Cation Channel | - |
dc.subject.MESH | TRPM Cation Channels/genetics | - |
dc.subject.MESH | TRPM Cation Channels/metabolism* | - |
dc.subject.MESH | Transient Receptor Potential Channels/metabolism | - |
dc.title | Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | 생체방어연구센터 | - |
dc.contributor.googleauthor | Su-Hwa Kim | - |
dc.contributor.googleauthor | Joo-Hyun Nam | - |
dc.contributor.googleauthor | Eun-Jung Park | - |
dc.contributor.googleauthor | Byung-Joo Kim | - |
dc.contributor.googleauthor | Sung-Joon Kim | - |
dc.contributor.googleauthor | Insuk So | - |
dc.contributor.googleauthor | Ju-Hong Jeon | - |
dc.identifier.doi | 10.1016/j.bbadis.2008.09.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01267 | - |
dc.relation.journalcode | J00290 | - |
dc.identifier.eissn | 1878-2434 | - |
dc.identifier.pmid | 18955132 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0925443908001877 | - |
dc.subject.keyword | Menthol | - |
dc.subject.keyword | TRPM8 | - |
dc.subject.keyword | Ca2+ | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | Cell death | - |
dc.contributor.alternativeName | Nam, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Nam, Joo Hyun | - |
dc.citation.volume | 1792 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, Vol.1792(1) : 33-38, 2009 | - |
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