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대장과 직장에 발생한 위장관 간질성 종양의 임상 병리학적 분석

Other Titles
 Clinicopathologic Analysis of Gastrointestinal Stromal Tumors of the Colon and Rectum 
Authors
 최성훈  ;  김서전  ;  최윤정  ;  민병소  ;  김진수  ;  백승혁  ;  김남규  ;  강중구 
Citation
 Journal of the Korean Society of Coloproctology, Vol.25(5) : 323-333, 2009 
Journal Title
Journal of the Korean Society of Coloproctology(대한대장항문학회지)
ISSN
 2287-9714 
Issue Date
2009
Keywords
GISTs ; Colorectum ; Treatment ; Recurrence
Abstract
Purpose: This study’s aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors.

Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008.

Results: Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health’s (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group.

Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor’s histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.
Files in This Item:
T200905056.pdf Download
DOI
10.3393/jksc.2009.25.5.323
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Jin Soo(김진수)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105710
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