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저산소 상태의 백서 심근세포에서 Regucalcin의 특이적 발현 및 역할

Other Titles
 Differential Expression of Regucalcin (SMP30) and Its Function in Hypoxic Cardiomyocytes 
Authors
 임소연  ;  송병욱  ;  차민지  ;  최은주  ;  함온주  ;  이창연  ;  최성용  ;  이세연  ;  장양수  ;  황기철 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.6(13) : 1273-1281, 2009 
Journal Title
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1738-2696 
Issue Date
2009
Keywords
Regucalcin ; calcium ; ischemia ; cardiomyocytes
Abstract
Regucalcin (SMP30) has been proposed to be involved in the maintenance of calcium homeostasis. Although the expression of regucalcin was regulated in the liver and kidney during the embryogenesis and maturation of these tissues, the roles of regucalcin were not defined yet in heart. This study focused on the investigation of the differential expression changes in regucalcin and its function in hypoxic cardiomyocytes. The expression level of regucalcin was the highest in 7 days after neonatal stage of rat heart. In hypoxic condition, reactive oxygen species (ROS) production and calcium level were decreased in regucalcin-overexpressed cardiomyocytes about 60% compared to normal cells. Regucalcin-transfected cells were slowly induced cell death in H2O2 treated condition and not reduced proliferation in hypoxic condition. In proliferation-related signals, PKC-MEK1/2-ERK1/2 activation of regucalcin-overexpressed cells was recovered in hypoxia, compared to hypoxic cardiomyocytes, and expression of proto-oncogene was only affected c-myc by regucalcin. Transfected cardiomyocytes demonstrated that apoptotic signal was hampered in regucalcin-regulated manner. In conclusion, these data suggest that regucalcin may regulate proliferation and cell death in cardiomyocytes via calcium homeostasis.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105613
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