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Gh Mediates α1-Adrenoceptor-Stimulated Hypertrophy Following Ischemia/Reperfusion in Cardiomyocytes

Authors
 Me Jin Kim  ;  Heesang Song  ;  Byeong-Wook Song  ;  Soyeon Lim  ;  Min-Ji Cha  ;  Eunju Choi  ;  Onju Ham  ;  Chang Yeon Lee  ;  Seong Yong Choi  ;  Se-Yeon Lee  ;  Ill Tae Hwang  ;  Yangsoo Jang  ;  Ki-Chul Hwang 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.6(13) : 1282-1289, 2009 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
ISSN
 1738-2696 
Issue Date
2009
Keywords
Gh ; α1-adrenoceptor ; ischemia/reperfusion ; reactive oxygen species ; hypertrophy
Abstract
Ischemia/reperfusion (I/R) has been associated with ventricular (LV) remodeling, including induction of
hypertrophy. Stimulation of α1-Adrenoceptors (ARs) has been implicated in the pathogenesis of cardiac hypertrophy.
The present study is to test the hypothesis that α1-AR-mediated hypertrophy is selectively mediated via the oxidative
modification of Gh during hypoxia/reoxygenation (H/R) or I/R. Reactive oxygen species (ROS) was increased
in H/R and expression level of membrane Gh. To further address involvement of Gh in hypertrophic response, specific
relation of Gh was confirmed by using Gh overexpression and blocking into cardiomyocytes. Mainly increased
membrane Gh protein by ROS has a more sensitive effect on myocardial hypertrophy through MEK1,2/ERKs signal
transduction pathway, but induction of proto-oncogene except c-fos and expression of PLC δ1 was independent in
ROS condition. These results provide that ROS production by I/R mediates Gh protein increment and Gh protein
leads to more specific responsiveness to NE-stimulated hypertrophic cardiomyocytes
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105608
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