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유방암에서 Survivin 발현의 예후인자적 가치

DC FieldValueLanguage
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author양우익-
dc.contributor.author오재원-
dc.contributor.author이경식-
dc.contributor.author이미정-
dc.date.accessioned2015-04-24T17:32:03Z-
dc.date.available2015-04-24T17:32:03Z-
dc.date.issued2009-
dc.identifier.issn1738-6756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105581-
dc.description.abstractPURPOSE: Survivin is a member of the inhibitors of apoptosis family. It has recently comes into the limelight as a promising tumor marker, but many previous reports have shown controversial results regarding the significance and prognostic value of a survivin expression. In this study we determined the correlation between the survivin expression and the conventional prognostic markers and we also investigated the outcomes according to the localization of the survivin expression. METHODS: Tissue microarray (TMA) blocks were made with formalin-fixed paraffin-embedded tissues from 185 breast cancer patients and the immunohistochemical staining was done using an anti-survivin antibody. Among these, 157 patients were available for a survivin expression. The conventional clinicopathologic features and overall survival were correlated with the localization of the survivin expression. RESULTS: Survivin was expressed in 101 breast cancers (64.3%). A higher cytoplasmic survivin expression were noted in the older group (p=0.003), in the node-negative cancers (p=0.012), in the earlier tumor stages (p=0.012) and in the cancers that had not been treated with adjuvant chemotherapy (p=0.014). On the contrary, a higher nuclear survivin expression was inversely correlated with an estrogen expression (p=0.006) and a progesterone receptor (p=0.043) expression. In terms of survival, a cytoplasmic expression was associated with improved overall survival (p=0.01) but a nuclear survivin expression was correlated with unfavorable overall survival (p=0.002). A high cytoplasmic to nuclear ratio of survivin was associated with improved overall survival (p=0.001) conversely, increased nuclear to cytoplasmic survivin ratio was correlated with unfavorable overall survival (p<0.0001). Multivariate analysis revealed that nuclear survivin expression (p=0.001) and high nuclear to cytoplasmic survivin ratio (p=0.012) were independent predictor of overall survival. CONCLUSION: Survivin is frequently expressed in primary breast cancer. A cytoplasmic survivin expression is a good prognostic predictor for patients with axillary node negative early breast cancers and a nuclear survivin expression is a worse independent predictor of overall survival for patients with axillary node positive breast cancers-
dc.description.statementOfResponsibilityopen-
dc.format.extent285~294-
dc.relation.isPartOfJOURNAL OF BREAST CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title유방암에서 Survivin 발현의 예후인자적 가치-
dc.title.alternativeThe Prognostic Significance of Survivin Expression in Breast Cancer.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthor오재원-
dc.contributor.googleauthor양우익-
dc.contributor.googleauthor이미정-
dc.contributor.googleauthor박세호-
dc.contributor.googleauthor박병우-
dc.contributor.googleauthor이경식-
dc.identifier.doi10.4048/jbc.2009.12.4.285-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02396-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA02300-
dc.contributor.localIdA02646-
dc.contributor.localIdA02775-
dc.relation.journalcodeJ01279-
dc.identifier.eissn2092-9900-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordPrognostic factor-
dc.subject.keywordSurvivin-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameOh, Jae Won-
dc.contributor.alternativeNameLee, Kyong Sik-
dc.contributor.alternativeNameLee, Mi Jeong-
dc.contributor.affiliatedAuthorOh, Jae Won-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Kyong Sik-
dc.contributor.affiliatedAuthorLee, Mi Jeong-
dc.citation.volume12-
dc.citation.number4-
dc.citation.startPage285-
dc.citation.endPage294-
dc.identifier.bibliographicCitationJOURNAL OF BREAST CANCER, Vol.12(4) : 285-294, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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