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AML1-ETO 양성인 양표현형 급성 백혈병의

Other Titles
 A case of biphenotypic acute leukemia with expression of the AML1-ETO gene rearrangement 
Authors
 서주희  ;  이혜원  ;  임주은  ;  정주원  ;  최종락  ;  양우익  ;  민유홍 
Citation
 Korean Journal of Medicine, Vol.76(5) : 617-621, 2009 
Journal Title
 Korean Journal of Medicine 
ISSN
 1738-9364 
Issue Date
2009
Keywords
Biphenotypic acute leukemia ; AML1-ETO fusion protein ; Human
Abstract
Biphenotypic acute leukemia (BAL) is a subtype of acute leukemia that expresses two different mmunophenotypic lineages, most commonly myeloid and either B- or T-lymphoid lineages. This entity has been defined by a scoring system proposed by the European Group for the Immunological Characterization of Leukemias (EGIL). The prognosis of BAL is regarded as being worse than either acute lymphoid or myeloid leukemia that does not show lineage ambiguity. However, a treatment strategy for BAL has not yet been established. We experienced a case of BAL with the t(8;21) translocation, a favorable cytogenetic rearrangement in acute myeloid leukemia (AML). The patient was successfully treated with cytarabine and anthracycline for induction and consolidation. The quantitative value of the AML1-ETO gene decreased after achieving complete hematologic remission. Thus, the AML1-ETO gene rearrangement in BAL may be associated with an acceptable response to the treatment strategy for AML
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Seo, Ju Hee(서주희)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lim, Ju Eun(임주은)
Chung, Joo Won(정주원)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105578
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