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Left atrial volume index: a predictor of adverse outcome in patients with hypertrophic cardiomyopathy

Authors
 Woo-In Yang  ;  Chi Young Shim  ;  Young Jin Kim  ;  Sung-Ai Kim  ;  Sang Jae Rhee  ;  Eui-Young Choi  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung  ;  Seung-Yun Cho  ;  Jong-Won Ha 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol.22(12) : 1338-1343, 2009 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 
ISSN
 0894-7317 
Issue Date
2009
MeSH
Cardiomyopathy, Hypertrophic/diagnostic imaging* ; Cardiomyopathy, Hypertrophic/mortality* ; Echocardiography/statistics & numerical data* ; Female ; Heart Atria/diagnostic imaging* ; Humans ; Korea ; Male ; Middle Aged ; Organ Size ; Outcome Assessment (Health Care)/methods* ; Prevalence ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Survival Analysis ; Survival Rate
Keywords
Hypertrophic cardiomyopathy ; Left atrial volume ; Prognosis
Abstract
BACKGROUND: Despite the relatively benign course for the majority of patients with hypertrophic cardiomyopathy (HCM), this disease may cause sudden cardiac death and progressive heart failure (HF). The aim of this study was to investigate useful parameters for predicting adverse outcomes of HCM, including echocardiographic parameters, cardiac magnetic resonance (CMR), and clinical markers. METHODS: Eighty-one patients with nonapical HCM (51 men; mean age, 57 +/- 14 years) who underwent CMR and echocardiography were prospectively evaluated. Cardiovascular events were defined as hospitalization for worsening HF, stroke, or cardiovascular death. RESULTS: During the mean follow-up period of 41 +/- 17 months, there were 17 cardiovascular events (5 deaths, 7 hospitalizations for worsening HF, and 5 strokes). Univariate analysis showed that older age, atrial fibrillation, elevated E/E' ratio, increased left atrial (LA) volume index, presence of mitral regurgitation grade > 2, New York Heart Association class III or IV, and late gadolinium enhancement >or= 6% were associated with cardiovascular events. In multivariate Cox regression analysis, increased LA volume index was found to be an independent predictor of cardiovascular events (for each 5 mL/m(2) increase, hazard ratio, 1.28; 95% confidence interval, 1.10-1.48; P < .01). Increased LA volume index was also revealed to be an independent predictor for cardiovascular events other than death (for each 5 mL/m(2) increase, hazard ratio, 1.44; 95% confidence interval, 1.12-1.83; P < .01). CONCLUSION: LA volume index is independently associated with adverse outcomes in patients with HCM and provides additional prognostic information.
Full Text
http://www.sciencedirect.com/science/article/pii/S0894731709008591
DOI
10.1016/j.echo.2009.09.016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Yang, Woo In(양우인)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105494
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