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Adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided versus empirical chemotherapy in unresectable non-small cell lung cancer

Authors
 YONG WHA MOON  ;  JOO HYUK SOHN  ;  YONG TAI KIM  ;  HYUN CHANG  ;  JAE HEON JEONG  ;  YOUNG JOO LEE  ;  JOON CHANG  ;  SE KYU KIM  ;  MINKYU JUNG  ;  SOOJUNG HONG  ;  SUNG HO CHOI  ;  JOO-HANG KIM 
Citation
 ANTICANCER RESEARCH, Vol.29(10) : 4243-4249, 2009 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2009
Keywords
Non-small cell lung cancer ; in vitro assay-guided hemotherapy ; em/*-al chemotherapy.
Abstract
BACKGROUND: We retrospectively compared adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided and empirical chemotherapies for unresectable non-small cell lung cancer (NSCLC) in this case-control study. PATIENTS AND METHODS: Unresectable NSCLC patients receiving ATP-CRA-guided platinum-based doublets as first-line therapy were enrolled as cases (n=27; 14 platinum-sensitive and 13 platinum-resistant patients). Performance status, stage, and chemotherapeutic regimen-matched patients receiving empirical chemotherapy were selected from the retrospective database as controls (n=93) in a case to control ratio of approximately 1:3. RESULTS: Response rate and survival (progression-free; overall) in both groups were not significantly different. However, the platinum-sensitive subgroup by ATP-CRA showed a higher response rate than the empirical group (71 versus 38%; p=0.023) with a trend toward longer progression-free survival (8.7 versus 4.8 months for platinum-sensitive versus empirical; p=0.223) and overall survival (not reached versus 12.6 months for platinum-sensitive versus empirical for p=0.134). CONCLUSION: ATP-CRA may be helpful in selecting platinum-responsive patients in unresectable NSCLC. We consider that nonplatinum doublets in platinum-resistant patients by ATP-CRA may be a more adapted approach than platinum-based doublets in future clinical trials
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Joo Hang(김주항)
Moon, Yong Wha(문용화)
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
Lee, Young Joo(이영주)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chang, Hyun(장현)
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
Jung, Jae Hun(정재헌)
Hong, Soo Jung(홍수정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105486
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