Cited 12 times in
Experimental and computational characterization of biological liquid crystals: a review of single-molecule bioassays.
DC Field | Value | Language |
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dc.contributor.author | 양재문 | - |
dc.date.accessioned | 2015-04-24T17:27:31Z | - |
dc.date.available | 2015-04-24T17:27:31Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105437 | - |
dc.description.abstract | Quantitative understanding of the mechanical behavior of biological liquid crystals such as proteins is essential for gaining insight into their biological functions, since some proteins perform notable mechanical functions. Recently, single-molecule experiments have allowed not only the quantitative characterization of the mechanical behavior of proteins such as protein unfolding mechanics, but also the exploration of the free energy landscape for protein folding. In this work, we have reviewed the current state-of-art in single-molecule bioassays that enable quantitative studies on protein unfolding mechanics and/or various molecular interactions. Specifically, single-molecule pulling experiments based on atomic force microscopy (AFM) have been overviewed. In addition, the computational simulations on single-molecule pulling experiments have been reviewed. We have also reviewed the AFM cantilever-based bioassay that provides insight into various molecular interactions. Our review highlights the AFM-based single-molecule bioassay for quantitative characterization of biological liquid crystals such as proteins. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 4009~4032 | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomechanical Phenomena | - |
dc.subject.MESH | Hydrogen Bonding | - |
dc.subject.MESH | Liquid Crystals/chemistry* | - |
dc.subject.MESH | Microscopy, Atomic Force | - |
dc.subject.MESH | Models, Chemical* | - |
dc.subject.MESH | Molecular Dynamics Simulation* | - |
dc.subject.MESH | Protein Unfolding | - |
dc.subject.MESH | Proteins/chemistry | - |
dc.subject.MESH | Thermodynamics | - |
dc.title | Experimental and computational characterization of biological liquid crystals: a review of single-molecule bioassays. | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Kilho Eom | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Jinsung Park | - |
dc.contributor.googleauthor | Gwonchan Yoon | - |
dc.contributor.googleauthor | Young Soo Sohn | - |
dc.contributor.googleauthor | Shinsuk Park | - |
dc.contributor.googleauthor | Dae Sung Yoon | - |
dc.contributor.googleauthor | Sungsoo Na | - |
dc.contributor.googleauthor | Taeyun Kwon | - |
dc.identifier.doi | 10.3390/ijms10094009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 19865530 | - |
dc.subject.keyword | single-molecule experiments | - |
dc.subject.keyword | atomic force microscope (AFM) | - |
dc.subject.keyword | coarse-grained molecular dynamics simulation | - |
dc.subject.keyword | coarse-grained model | - |
dc.subject.keyword | in vitro molecular recognitions | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.citation.volume | 10 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4009 | - |
dc.citation.endPage | 4032 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.10(9) : 4009-4032, 2009 | - |
dc.identifier.rimsid | 51690 | - |
dc.type.rims | ART | - |
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